{"id":"W2966500580","doi":"10.1161/jaha.119.012763","title":"Effects of Hormone Therapy on Heart Fat and Coronary Artery Calcification Progression: Secondary Analysis From the KEEPS Trial","year":2019,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Pfizer Pharmaceuticals; School of Medicine; University of California, San Francisco; York University; Aurora Foundation; University of Washington; National Center for Advancing Translational Sciences; University of Southern California; University of California, Los Angeles; National Institutes of Health; Bayer HealthCare; Yale University; Brigham and Women's Hospital; Johns Hopkins University; National Heart, Lung, and Blood Institute; Pfizer","keywords":"Medicine; Placebo; Epicardial adipose tissue; Internal medicine; Adipose tissue; Estrogen; Menopause; Hormone therapy; Cardiology; Endocrinology; Hormone replacement therapy (female-to-male); Coronary atherosclerosis; Calcification; Coronary artery disease; Gastroenterology; Pathology; Breast cancer; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005162244,0.00008720909,0.0006114283,0.00006785743,0.00006898881,0.00001822349,0.00007071752,0.0000435539,0.00000781172],"category_scores_gemma":[0.0001287158,0.00004726282,0.0007550533,0.0003464073,0.00004697508,0.00006739482,0.00001859903,0.0002604865,0.000002861358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008871592,"about_ca_system_score_gemma":0.00006722687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003286371,"about_ca_topic_score_gemma":0.000001007154,"domain_scores_codex":[0.9983845,0.0005457025,0.0002926323,0.000110045,0.0005692017,0.00009791854],"domain_scores_gemma":[0.9983819,0.0006283726,0.0005712112,0.0002508001,0.0001058249,0.00006189409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01416635,0.000372453,0.9069992,0.000009517428,0.005420187,0.00000535481,0.0003276956,0.00002248371,0.0603577,0.000001884419,0.003583033,0.008734148],"study_design_scores_gemma":[0.007931748,0.001054542,0.9848597,0.00004428776,0.001618903,0.00001384134,0.00006232155,0.00004258102,0.003711101,0.00002186853,0.0005910167,0.00004811218],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928938,0.002769109,0.00001033363,0.003605884,0.0001762759,0.0005145314,0.000008456685,0.000005065318,0.00001655138],"genre_scores_gemma":[0.9981661,0.0003654026,0.0000524182,0.0009750331,0.0003788382,0.000004527104,0.000005484651,0.000007834787,0.00004436404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07786048,"threshold_uncertainty_score":0.1927322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007390147477297589,"score_gpt":0.2657036135674061,"score_spread":0.2583134660901085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}