{"id":"W2966543215","doi":"10.1111/bph.14814","title":"Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function","year":2019,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Chief Scientist Office; Abertay University","keywords":"Hyperactivation; Acrosome reaction; Sperm; Asthenozoospermia; Sperm motility; Motility; Intracellular; Fertilisation; Cell biology; Pharmacology; Biology; Chemistry; Male infertility; Andrology; Infertility; Reproductive technology; Medicine; Cryopreservation; Embryo","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363449,0.00027985,0.000349919,0.0002086166,0.00009975304,0.0001814127,0.0001660804,0.0002046997,0.002394279],"category_scores_gemma":[0.0001736446,0.00007698142,0.000228569,0.000123448,0.0001332512,0.0001206285,0.0001114129,0.0002869378,0.0002614918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001644455,"about_ca_system_score_gemma":0.0001127666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004569057,"about_ca_topic_score_gemma":0.001420309,"domain_scores_codex":[0.9999306,0.00001214944,0.000009285611,0.00001570589,0.00001955502,0.0000127314],"domain_scores_gemma":[0.9999304,0.00002259121,0.00001504466,0.000005262168,0.00001590527,0.00001089291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002471869,0.00004849185,0.0002598875,0.0001228482,0.00001221787,0.0001180097,0.00001699742,0.0001261509,0.9931208,0.000029392,0.00008944554,0.005808582],"study_design_scores_gemma":[0.0001542495,0.004609061,0.009544789,0.00002428364,0.0001039472,0.001140548,0.00004438286,0.0009828242,0.9785695,0.00003339762,0.004780585,0.00001252102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798415,0.01247345,0.003814251,0.0002146945,0.00006724621,0.0001531066,0.0006949235,0.0001437577,0.002597084],"genre_scores_gemma":[0.9921813,0.003049012,0.002469316,0.0001130218,0.00002405903,0.00003393418,0.000436935,0.0000115857,0.001680796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002394279,"threshold_uncertainty_score":0.008009672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411338318056236,"score_gpt":0.3008956607402497,"score_spread":0.2767822775596874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}