{"id":"W2966568342","doi":"10.1165/rcmb.2018-0373oc","title":"Toll-like Receptor 8 Stability is Regulated by Ring Finger 216 in Response to Circulating MicroRNAs","year":2019,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Heart, Lung, and Blood Institute; U.S. Department of Veterans Affairs","keywords":"Ubiquitin ligase; Innate immune system; Cell biology; ARDS; Ubiquitin; microRNA; Toll-like receptor; RNA; Biology; Immune system; Protein degradation; Receptor; Small interfering RNA; TLR3; Proteasome; Immunology; Medicine; Biochemistry; Internal medicine; Gene; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002412063,0.0002515067,0.0003374218,0.0002274546,0.000157966,0.0003586159,0.0001218878,0.0003062653,0.001524876],"category_scores_gemma":[0.0003730858,0.0001841582,0.0003782575,0.0001230034,0.0001674489,0.0001640096,0.0002118993,0.0002609633,0.0006438129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002993208,"about_ca_system_score_gemma":0.00009291617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002097005,"about_ca_topic_score_gemma":0.0001649891,"domain_scores_codex":[0.9997769,0.00003913084,0.0000245291,0.00006350835,0.00003911867,0.0000568659],"domain_scores_gemma":[0.9997476,0.00002746996,0.0001261124,0.00001910619,0.00003499958,0.00004473919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008688515,0.00001708291,0.001535888,0.00003221797,0.00001195083,0.00009135014,0.00001978296,0.00003552495,0.9964806,0.00003431349,0.00006755099,0.0008048267],"study_design_scores_gemma":[0.00005162876,0.0004294205,0.08456404,0.000008069876,0.00003612744,0.0007821569,0.00007709525,0.00164405,0.9106439,0.0001010853,0.001645089,0.00001726687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965351,0.00116616,0.001434003,0.00007060536,0.00002857128,0.00001203431,0.0003822014,0.00004320466,0.0003281724],"genre_scores_gemma":[0.9977642,0.00023354,0.0007673142,0.0000386242,0.00001488045,0.00002110099,0.0002939283,0.000009656132,0.0008567735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001524876,"threshold_uncertainty_score":0.005101204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005309645634729737,"score_gpt":0.2285897206265783,"score_spread":0.2232800749918486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}