{"id":"W2966588009","doi":"10.1111/acel.13026","title":"Long‐term repopulation of aged bone marrow stem cells using young Sca‐1 cells promotes aged heart rejuvenation","year":2019,"lang":"en","type":"article","venue":"Aging Cell","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Science and Technology Planning Project of Guangdong Province; Canadian Institutes of Health Research; Bureau of Education of Guangzhou Municipality","keywords":"Biology; Stem cell; Homing (biology); Telomerase; Bone marrow; CXCR4; BMI1; CD34; Cancer research; Stem cell factor; Immunology; Cell biology; Haematopoiesis; Molecular biology; Chemokine; Inflammation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001609469,0.0002855035,0.0002932674,0.0001812697,0.00008140583,0.0001833024,0.0001160489,0.0001682387,0.001021576],"category_scores_gemma":[0.00004884092,0.0001133234,0.0002456607,0.00007528288,0.0001423447,0.0001486647,0.0001653924,0.0004474432,0.0002746971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009644521,"about_ca_system_score_gemma":0.0001020354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003168967,"about_ca_topic_score_gemma":0.0006250466,"domain_scores_codex":[0.9999318,0.000007969515,0.000008769252,0.00001755645,0.00001601128,0.00001780942],"domain_scores_gemma":[0.999894,0.000005935176,0.00003187761,0.00001130207,0.000009351485,0.00004762342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005705986,0.0000302505,0.000248635,0.00001792459,0.0000035553,0.00003140968,0.00001621777,0.00002941064,0.9987882,0.00003218283,0.00002521597,0.000719992],"study_design_scores_gemma":[0.00003411735,0.001748546,0.01810831,0.00001977027,0.00004682477,0.0004241078,0.0000687141,0.001110618,0.9743063,0.00006916156,0.004056809,0.000006714492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968846,0.001032998,0.001386632,0.00002456183,0.0000203723,0.00001869992,0.0001646198,0.00005049436,0.0004170322],"genre_scores_gemma":[0.9950611,0.0006318026,0.001401004,0.00004540185,0.00001490099,0.00003500228,0.0004343962,0.00001777541,0.002358537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021576,"threshold_uncertainty_score":0.003417492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379324780815199,"score_gpt":0.2351132513930344,"score_spread":0.2213200035848824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}