{"id":"W2966639800","doi":"10.1002/mas.21598","title":"Proteome analysis of tissues by mass spectrometry","year":2019,"lang":"en","type":"review","venue":"Mass Spectrometry Reviews","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Chemistry; Lysis; Sample preparation; Proteome; Lysis buffer; Chromatography; Trypsin; Ammonium bicarbonate; Computational biology; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011381,0.002038915,0.001315122,0.004714949,0.001067874,0.001658891,0.001158442,0.00135849,0.00412578],"category_scores_gemma":[0.001280761,0.0006170204,0.001509513,0.002726761,0.0005610403,0.00136132,0.001339572,0.001938663,0.00673876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004878432,"about_ca_system_score_gemma":0.0007406147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000679128,"about_ca_topic_score_gemma":0.0009018978,"domain_scores_codex":[0.9986975,0.0001328496,0.0001128747,0.0005200314,0.0003896512,0.0001471667],"domain_scores_gemma":[0.9995185,0.00008743473,0.00009383795,0.00007274897,0.0001834961,0.00004389486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002419738,0.00009251344,0.001801081,0.001083136,0.0001879875,0.0004490964,0.000157542,0.0004278578,0.9635708,0.001075053,0.003838258,0.02707469],"study_design_scores_gemma":[0.00005152634,0.000537815,0.03256775,0.0004681719,0.0004008011,0.002944835,0.0003435352,0.01220815,0.8220942,0.00388372,0.1242877,0.0002116882],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.2916051,0.0564009,0.5518681,0.001837202,0.002607035,0.001603188,0.0528623,0.01354202,0.02767406],"genre_scores_gemma":[0.262883,0.06905662,0.5672954,0.002275588,0.0009416511,0.003206114,0.06718677,0.002843045,0.02431191],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004714949,"threshold_uncertainty_score":0.01380211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04587801501280375,"score_gpt":0.3598798931909714,"score_spread":0.3140018781781677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}