{"id":"W2966639800","doi":"10.1002/mas.21598","title":"Proteome analysis of tissues by mass spectrometry","year":2019,"lang":"en","type":"review","venue":"Mass Spectrometry Reviews","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Chemistry; Lysis; Sample preparation; Proteome; Lysis buffer; Chromatography; Trypsin; Ammonium bicarbonate; Computational biology; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0007641509,0.001289999,0.008767501,0.001550812,0.0001012517,0.00008945157,0.001859266,0.0008428174,0.007121583],"category_scores_gemma":[0.0001735627,0.001080687,0.003447451,0.007388251,0.0001389379,0.0001409615,0.0002311352,0.001383163,0.0005271025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006779149,"about_ca_system_score_gemma":0.0001268524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001798758,"about_ca_topic_score_gemma":0.000001303831,"domain_scores_codex":[0.9939125,0.0001625052,0.002880128,0.001587522,0.0006047297,0.0008526279],"domain_scores_gemma":[0.9928563,0.0002385389,0.003314304,0.003262339,0.00009786429,0.0002306711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001623307,0.0005705986,0.00009549246,0.1807335,0.00903028,0.00001728971,0.00002321442,0.000001937643,0.06923075,0.003847928,0.01031527,0.7261175],"study_design_scores_gemma":[0.00009805506,0.00005707403,2.677934e-7,0.004979163,0.01038877,0.000008642336,0.000004683796,0.000009309359,0.004922188,0.0005825129,0.9779585,0.0009908247],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002021177,0.9365155,0.04444968,0.00002823181,0.00004955334,0.002618087,0.001270476,0.0002213732,0.01484509],"genre_scores_gemma":[0.00000178888,0.8538617,0.1336104,0.00001669288,0.0001888925,0.001604263,0.001667545,0.0001824597,0.008866293],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9676433,"threshold_uncertainty_score":0.9999852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04587801501280375,"score_gpt":0.3598798931909714,"score_spread":0.3140018781781677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}