{"id":"W2966645159","doi":"10.1101/723478","title":"A loss-of-function mutation in <i>Itgal</i> contributes to the high susceptibility of Collaborative Cross strain CC042 to <i>Salmonella</i> infections","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Complementation; Spleen; Salmonella; CD8; Splenocyte; Allele; Quantitative trait locus; Intracellular parasite; Phenotype; Immunology; Immune system; Microbiology; Genetics; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000232703,0.0008587955,0.0002797764,0.0009276337,0.0002558834,0.0003405598,0.0004712689,0.0006635193,0.004232339],"category_scores_gemma":[0.0002356558,0.0002340968,0.0005547698,0.0003294626,0.0004045609,0.0001176541,0.0004461907,0.001046203,0.0006680911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002972826,"about_ca_system_score_gemma":0.0001785292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001135491,"about_ca_topic_score_gemma":0.001086914,"domain_scores_codex":[0.9996717,0.00005602218,0.00003771255,0.00008754377,0.00007072445,0.00007640342],"domain_scores_gemma":[0.9992786,0.0001195487,0.0002536616,0.00005717975,0.00004114039,0.0002499296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001995422,0.00009952198,0.001067866,0.00001530806,0.0000140609,0.0002646562,0.00001596795,0.00003605634,0.9977983,0.00004911013,0.00006298155,0.0003766902],"study_design_scores_gemma":[0.0002476433,0.002969718,0.1746117,0.00007728078,0.0002412358,0.01256659,0.0003666972,0.003208717,0.7995036,0.0001346535,0.005991157,0.00008108401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979534,0.0001165546,0.0007335607,0.0000505768,0.00001664331,0.0000221851,0.0004578256,0.00003872373,0.0006103753],"genre_scores_gemma":[0.9958211,0.0001035089,0.0009477822,0.000085239,0.00001946419,0.00003706123,0.001072935,0.00007986817,0.001833067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004232339,"threshold_uncertainty_score":0.01415861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008331273002887345,"score_gpt":0.2339071557374923,"score_spread":0.225575882734605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}