{"id":"W2966680488","doi":"10.1093/ofid/ofz338","title":"Impact of Tenofovir-Based Pre-exposure Prophylaxis on Biomarkers of Bone Formation, Bone Resorption, and Bone Mineral Metabolism in HIV-Negative Adults","year":2019,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; Bill and Melinda Gates Foundation; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences","keywords":"Medicine; Bone remodeling; N-terminal telopeptide; Bone mineral; Emtricitabine; Internal medicine; Pre-exposure prophylaxis; Bone resorption; Tenofovir; Placebo; Endocrinology; Physiology; Osteoporosis; Viral load; Human immunodeficiency virus (HIV); Osteocalcin; Immunology; Antiretroviral therapy; Pathology; Alkaline phosphatase; Men who have sex with men","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001400262,0.0002285901,0.0006292996,0.0004896761,0.00009018521,0.0000225066,0.00007292377,0.0001065267,0.0001264687],"category_scores_gemma":[0.000182872,0.0001767387,0.000149515,0.0005835796,0.00009756585,0.0003152276,0.0000597505,0.0001246686,0.0000274314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725083,"about_ca_system_score_gemma":0.00027881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001981169,"about_ca_topic_score_gemma":0.000168299,"domain_scores_codex":[0.9983819,0.0001049271,0.0006669707,0.0003203573,0.000244827,0.0002809787],"domain_scores_gemma":[0.9984802,0.0001212081,0.0004452046,0.0004458566,0.0003044856,0.0002030615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004304922,0.002692709,0.9858923,0.0004270523,0.0002158798,0.00001064765,0.0003556421,0.0001340797,0.000941882,0.0001895239,0.0008426978,0.003992679],"study_design_scores_gemma":[0.01177028,0.004142455,0.981665,0.0006999446,0.0001470161,0.00002942153,0.0000926395,0.0005568021,0.0004045554,0.0002807048,0.00005559079,0.0001555817],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939826,0.0006301061,0.00002297038,0.0003194334,0.00003509232,0.002914062,0.000488808,0.0000295841,0.001577326],"genre_scores_gemma":[0.998851,0.00007449054,0.0001978132,0.00008512061,0.000009981374,0.0002177512,0.0003563437,0.00002642593,0.0001810798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007465358,"threshold_uncertainty_score":0.7207196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006875298972155355,"score_gpt":0.2859219674804134,"score_spread":0.2790466685082581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}