{"id":"W2966680488","doi":"10.1093/ofid/ofz338","title":"Impact of Tenofovir-Based Pre-exposure Prophylaxis on Biomarkers of Bone Formation, Bone Resorption, and Bone Mineral Metabolism in HIV-Negative Adults","year":2019,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; Bill and Melinda Gates Foundation; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences","keywords":"Medicine; Bone remodeling; N-terminal telopeptide; Bone mineral; Emtricitabine; Internal medicine; Pre-exposure prophylaxis; Bone resorption; Tenofovir; Placebo; Endocrinology; Physiology; Osteoporosis; Viral load; Human immunodeficiency virus (HIV); Osteocalcin; Immunology; Antiretroviral therapy; Pathology; Alkaline phosphatase; Men who have sex with men","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008259888,0.0002817642,0.0005437474,0.0001622185,0.0001586616,0.000332513,0.0001655846,0.0003913502,0.00104053],"category_scores_gemma":[0.001383871,0.0001038749,0.0003760879,0.0001820622,0.0001602161,0.0001715707,0.0001803551,0.0004253121,0.00006160629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001841821,"about_ca_system_score_gemma":0.0002560655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001286244,"about_ca_topic_score_gemma":0.0022036,"domain_scores_codex":[0.9995605,0.0002178686,0.0000392922,0.00006447901,0.00006752072,0.00005027735],"domain_scores_gemma":[0.9993692,0.0002245385,0.0001382183,0.00002883757,0.00004539223,0.0001938054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1164419,0.003350666,0.7593689,0.0004811955,0.001721341,0.0002329217,0.0001736507,0.0003420588,0.0112394,0.00008351694,0.0004332525,0.1061312],"study_design_scores_gemma":[0.002247769,0.03170589,0.9618342,0.00005153809,0.00090195,0.0002992288,0.00008083389,0.0004901848,0.001710387,0.00006854894,0.0006001221,0.000009348425],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957755,0.003598758,0.00003771259,0.0000623877,0.00001398417,0.00002594768,0.0001142202,0.00000305256,0.0003682941],"genre_scores_gemma":[0.9993985,0.0003095149,0.00007612271,0.00005226602,0.00001150943,0.00001187204,0.00005568604,4.494415e-7,0.0000841422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286244,"threshold_uncertainty_score":0.004368305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006875298972155355,"score_gpt":0.2859219674804134,"score_spread":0.2790466685082581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}