{"id":"W2966690555","doi":"10.1073/pnas.1820683116","title":"Phase separation and clustering of an ABC transporter in <i>Mycobacterium tuberculosis</i>","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"ATP-binding cassette transporter; Biology; Mycobacterium tuberculosis; Transmembrane protein; Compartmentalization (fire protection); Phosphatase; Secretion; Cytoplasm; Threonine; Membrane protein; Bacteria; Mycobacterium; Cell biology; Serine; Microbiology; Biochemistry; Membrane; Transporter; Phosphorylation; Tuberculosis; Genetics; Enzyme; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004869424,0.00009099239,0.0001056099,0.0001308994,0.0002099668,0.0002722426,0.0001145394,0.0001645343,0.0004155459],"category_scores_gemma":[0.0001268328,0.0001008545,0.00008165797,0.00008195816,0.0001897563,0.0001185925,0.0001348675,0.0002395941,0.000218939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003849203,"about_ca_system_score_gemma":0.0001405029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002255,"about_ca_topic_score_gemma":0.0009440838,"domain_scores_codex":[0.9999509,0.000005396765,0.000002495304,0.00001435259,0.00001450692,0.00001227471],"domain_scores_gemma":[0.9999421,0.000008917503,0.00001975597,0.000003920371,0.000012706,0.00001251285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003997445,0.000006833168,0.0005139859,0.00001828877,0.000002408407,0.00005354863,0.00001557704,0.0001568021,0.998215,0.0003162488,0.00005620235,0.0006051736],"study_design_scores_gemma":[0.000027753,0.0001341476,0.01327864,0.0000115168,0.00001189642,0.0005230517,0.00009261407,0.01008486,0.9727297,0.0007072258,0.002387004,0.0000115295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948774,0.000688811,0.002740821,0.0001550572,0.00001602516,0.00000692479,0.00006025569,0.00003453409,0.001420249],"genre_scores_gemma":[0.9980088,0.0001313333,0.001046899,0.0000326021,0.000003691437,0.000005858538,0.00006939372,0.00001034843,0.0006911339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002255,"threshold_uncertainty_score":0.002792835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822956479361907,"score_gpt":0.2988206610990237,"score_spread":0.2805910963054046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}