{"id":"W2966723948","doi":"10.1101/728071","title":"bioPROTACs as versatile modulators of intracellular therapeutic targets: Application to proliferating cell nuclear antigen (PCNA)","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Proliferating cell nuclear antigen; Ubiquitin; Ubiquitin ligase; Computational biology; Cell biology; Biology; Fusion protein; Intracellular; DNA repair; Proteolysis; DNA; Biochemistry; Recombinant DNA; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002450469,0.0003356293,0.0002066887,0.0001824666,0.0001263995,0.0003169547,0.0001618337,0.000294981,0.0004952385],"category_scores_gemma":[0.000113162,0.0000972189,0.0001857721,0.0001568923,0.0002390927,0.0001658902,0.0002073302,0.000459002,0.0001803639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003073645,"about_ca_system_score_gemma":0.0001609284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004273944,"about_ca_topic_score_gemma":0.0006362243,"domain_scores_codex":[0.9998906,0.00002360177,0.000008715524,0.00002330379,0.00003061171,0.00002317769],"domain_scores_gemma":[0.9999152,0.00001506146,0.00002833125,0.000008649084,0.00001339999,0.00001932712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000581919,0.0000253373,0.00004615803,0.00004871184,0.000004225131,0.00003713985,0.00001606319,0.0001930615,0.9961907,0.0001217358,0.00003449341,0.003224213],"study_design_scores_gemma":[0.000009876118,0.0003932251,0.0002139789,0.000003013017,0.000007148497,0.00009615278,0.000006929446,0.0004654558,0.9967206,0.00001612582,0.002063985,0.000003519572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674249,0.01247185,0.01604901,0.00028265,0.00006174653,0.0001848488,0.0001802055,0.0001803826,0.003164401],"genre_scores_gemma":[0.9863166,0.004082505,0.007905042,0.00007977811,0.00001816637,0.00004550235,0.0001232212,0.00001546581,0.001413644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004952385,"threshold_uncertainty_score":0.002230108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005681256266279807,"score_gpt":0.2041806745391205,"score_spread":0.1984994182728407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}