{"id":"W2966760111","doi":"10.1182/blood.v130.suppl_1.2524.2524","title":"The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; Mitochondrial DNA; Molecular biology; Mitochondrion; Respiratory chain; Oxidative phosphorylation; Phosphorylation; Nuclear DNA; DNA polymerase; DNA replication; DNA; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510563,0.000342401,0.0004306564,0.0002087429,0.0001559413,0.0002918071,0.000242023,0.00025901,0.001155414],"category_scores_gemma":[0.0001511533,0.000161811,0.000234264,0.000225617,0.000174211,0.0001833634,0.0001292591,0.0008086798,0.0002318869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565995,"about_ca_system_score_gemma":0.0002551492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001301505,"about_ca_topic_score_gemma":0.002537946,"domain_scores_codex":[0.9997833,0.00004184491,0.00003014562,0.00002696771,0.00006566098,0.00005201072],"domain_scores_gemma":[0.9999012,0.00001984894,0.00002000849,0.00001123224,0.00001364506,0.00003406608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005259356,0.0001707455,0.0002293767,0.0000571161,0.000008235294,0.00003986331,0.00002185821,0.00005998162,0.9964105,0.00008110514,0.00009239234,0.0023029],"study_design_scores_gemma":[0.000143477,0.002327726,0.00467903,0.000007507496,0.00002922485,0.0001803743,0.00003564421,0.0007585206,0.9873771,0.00004600066,0.004410383,0.000005003408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99321,0.003613322,0.001077832,0.000137565,0.00007369753,0.00005982551,0.0004316702,0.00006748266,0.0013287],"genre_scores_gemma":[0.9948457,0.001324563,0.001089678,0.00005554613,0.00001683286,0.00004069807,0.0007286429,0.00001016684,0.001888102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301505,"threshold_uncertainty_score":0.003865242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685630233478911,"score_gpt":0.2775191161008171,"score_spread":0.260662813766028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}