{"id":"W2966837801","doi":"10.1016/j.bbagen.2019.07.014","title":"Streptomyces IHF uses multiple interfaces to bind DNA","year":2019,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; McMaster University","keywords":"Nucleoid; Streptomyces coelicolor; DNA; Biology; Escherichia coli; Binding site; DNA supercoil; DNA-binding protein; Biophysics; Bacillus subtilis; DNA binding site; Cell biology; Crystallography; DNA replication; Biochemistry; Chemistry; Genetics; Promoter; Streptomyces; Transcription factor; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003943534,0.0006636056,0.0007341109,0.0004666872,0.0006322514,0.001164696,0.0007658452,0.0009959257,0.002471602],"category_scores_gemma":[0.0009824614,0.0004094059,0.0005366159,0.0003124001,0.000437965,0.0009733212,0.001171193,0.001149486,0.002120605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005998253,"about_ca_system_score_gemma":0.0003446719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007376201,"about_ca_topic_score_gemma":0.0006637267,"domain_scores_codex":[0.9994822,0.0000433345,0.00002634288,0.0000979783,0.0001446783,0.0002055483],"domain_scores_gemma":[0.9993044,0.0002195826,0.00005183195,0.0001053462,0.00006170318,0.0002570944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002715183,0.0000866271,0.001345328,0.00008885714,0.00001389154,0.0001902126,0.0000842507,0.0002139185,0.9851457,0.001177954,0.0003154869,0.0110664],"study_design_scores_gemma":[0.00003153755,0.0001138014,0.001631029,0.000009274163,0.00001067787,0.0002164453,0.0001507323,0.001133029,0.9918855,0.0003959411,0.004405059,0.0000169987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589967,0.001020716,0.03246054,0.0002061891,0.0001664248,0.00005192358,0.0001356737,0.0008622939,0.006099498],"genre_scores_gemma":[0.9848558,0.0002424271,0.01004416,0.0001503565,0.0000305827,0.00003522989,0.0004238161,0.0001296143,0.004088033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002471602,"threshold_uncertainty_score":0.008268297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008121015665376333,"score_gpt":0.2353464044608285,"score_spread":0.2272253887954522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}