{"id":"W2966886623","doi":"10.1101/734582","title":"A Universal Proximity CRISPR Cas12a Assay for Ultrasensitive Detection of Nucleic Acids and Proteins","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"","keywords":"Trans-activating crRNA; CRISPR; Nucleic acid; RNA; Primer (cosmetics); Deoxyribozyme; Computational biology; Chemistry; Primer extension; Molecular biology; DNA; Biology; Biochemistry; Cas9; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009240373,0.0009676845,0.0009244803,0.001044952,0.0005856106,0.0009341568,0.001010866,0.001244556,0.002656484],"category_scores_gemma":[0.001251101,0.0006706154,0.0004928511,0.0005478695,0.0008103838,0.0006589922,0.001325935,0.001918408,0.001767857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007349285,"about_ca_system_score_gemma":0.0005873367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005951914,"about_ca_topic_score_gemma":0.001245299,"domain_scores_codex":[0.9976435,0.000368839,0.0001314473,0.0009711952,0.0007212934,0.0001637483],"domain_scores_gemma":[0.9990846,0.000263896,0.0001914907,0.0001668435,0.0001339598,0.0001591494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002854484,0.00002198361,0.0001483778,0.00006644442,0.00001064616,0.00001934639,0.00002175594,0.0001034365,0.9953842,0.0002633942,0.0002091459,0.003722757],"study_design_scores_gemma":[0.000003710618,0.00005369201,0.0004038907,0.000005572434,0.00001058616,0.0001742421,0.00000681251,0.001378653,0.9953688,0.0001286644,0.002452829,0.00001252118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2421902,0.00501478,0.7373339,0.0004677832,0.0003592784,0.0004378717,0.001909689,0.006079684,0.006206806],"genre_scores_gemma":[0.523814,0.001803365,0.4586096,0.0004452178,0.0001049711,0.0006811923,0.0018119,0.000337489,0.01239228],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002656484,"threshold_uncertainty_score":0.008886814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007995669294864654,"score_gpt":0.2270466286869372,"score_spread":0.2190509593920725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}