{"id":"W2966901273","doi":"10.1074/jbc.ra119.009910","title":"Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbial biofilms","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Institute of Infection and Immunity; Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Fonds de Recherche du Québec - Santé; Western Economic Diversification Canada; Canadian Institutes of Health Research; National Institutes of Health; University of Saskatchewan; Hospital for Sick Children; National Institute of General Medical Sciences; Ministerio de Ciencia e Innovación; University of Toronto; Cystic Fibrosis Canada; McGill University; McGill University Health Centre; Biological and Environmental Research; Government of Ontario; U.S. Department of Energy; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source","keywords":"Aspergillus fumigatus; Biofilm; Microbiology; Fungal pathogen; Pathogen; Aspergillus; Pathogenic organism; Biology; Chemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003675398,0.0004941258,0.0007187969,0.00001564765,0.0001480606,0.0001534028,0.001197734,0.0007632584,0.01500062],"category_scores_gemma":[0.0002879385,0.000297935,0.000676797,0.0001271457,0.0002719615,0.0001826605,0.0002165418,0.001088472,0.00006342579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001313224,"about_ca_system_score_gemma":0.0001277959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002245192,"about_ca_topic_score_gemma":0.000001084753,"domain_scores_codex":[0.9975295,0.0000697944,0.000793294,0.0005724159,0.000467934,0.0005670618],"domain_scores_gemma":[0.9972757,0.0006125271,0.000721829,0.0008202246,0.0001502251,0.0004194947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004130593,0.0002374056,0.02680877,0.00005225173,0.0001645407,0.0002121983,0.0001884461,0.00000246292,0.9702139,0.000001438446,0.0006244013,0.001081074],"study_design_scores_gemma":[0.0009459467,0.00006208326,0.001939976,0.0001154573,0.00009676741,0.0004660978,0.001025272,0.00002638536,0.9862294,0.00008267667,0.008575412,0.000434595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911602,0.0008570601,0.000002135144,0.0004256117,0.0002295354,0.00005804365,0.0008439449,0.00004579711,0.006377702],"genre_scores_gemma":[0.9966702,0.0002272632,0.0001167833,0.0003797156,0.001620427,0.000004578115,0.0001797467,0.00003403933,0.0007671941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0248688,"threshold_uncertainty_score":0.9999472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03207127656291821,"score_gpt":0.2321916397288748,"score_spread":0.2001203631659566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}