{"id":"W2966901273","doi":"10.1074/jbc.ra119.009910","title":"Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbial biofilms","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Institute of Infection and Immunity; Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Fonds de Recherche du Québec - Santé; Western Economic Diversification Canada; Canadian Institutes of Health Research; National Institutes of Health; University of Saskatchewan; Hospital for Sick Children; National Institute of General Medical Sciences; Ministerio de Ciencia e Innovación; University of Toronto; Cystic Fibrosis Canada; McGill University; McGill University Health Centre; Biological and Environmental Research; Government of Ontario; U.S. Department of Energy; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source","keywords":"Aspergillus fumigatus; Biofilm; Microbiology; Fungal pathogen; Pathogen; Aspergillus; Pathogenic organism; Biology; Chemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006146305,0.0003018412,0.0001722868,0.0001083269,0.0001774549,0.0002098867,0.0001826165,0.0002597611,0.000836382],"category_scores_gemma":[0.00008027878,0.00007726523,0.000312926,0.0001466157,0.0001246082,0.0001218436,0.0001607609,0.0004193456,0.0002812985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003318017,"about_ca_system_score_gemma":0.0002555402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004280299,"about_ca_topic_score_gemma":0.005940897,"domain_scores_codex":[0.9999522,0.000006695134,0.00000278699,0.000007220178,0.00001893913,0.00001218378],"domain_scores_gemma":[0.9999821,0.000003218952,0.000003536207,0.000002053311,0.000003309018,0.000005726682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001250232,0.00002637892,0.0007323034,0.00003025382,0.00001140271,0.0001024622,0.000008010739,0.0002660929,0.9963175,0.000120116,0.0001186653,0.002141789],"study_design_scores_gemma":[0.00002764696,0.0002092046,0.008306985,0.000009098865,0.00002827073,0.0005790362,0.00007962116,0.002327793,0.9832541,0.0001395053,0.005030077,0.00000860908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930696,0.001261799,0.003317502,0.0002812142,0.00003683897,0.00001590366,0.0005428742,0.00005251165,0.001421816],"genre_scores_gemma":[0.9918272,0.0008021255,0.004085742,0.00009670162,0.00000379642,0.000006298051,0.001218105,0.00001340386,0.001946487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004280299,"threshold_uncertainty_score":0.008510768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03207127656291821,"score_gpt":0.2321916397288748,"score_spread":0.2001203631659566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}