{"id":"W2966919884","doi":"10.3390/cancers11081165","title":"Long-Term Dynamics of Three Dimensional Telomere Profiles in Circulating Tumor Cells in High-Risk Prostate Cancer Patients Undergoing Androgen-Deprivation and Radiation Therapy","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"CancerCare Manitoba Foundation","keywords":"Prostate cancer; Medicine; Telomere; Oncology; Circulating tumor cell; Surrogate endpoint; Internal medicine; Androgen deprivation therapy; Cancer; Radiation therapy; Prostate; Biopsy; Urology; Metastasis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088932,0.00007337698,0.0001629502,0.0002466114,0.0001127899,0.0003049445,0.0000797675,0.0001957658,0.0004249031],"category_scores_gemma":[0.0004765815,0.00007340316,0.00009009875,0.0002217183,0.00007754735,0.00009849515,0.00009587275,0.0002040233,0.000107733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266997,"about_ca_system_score_gemma":0.00007992291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001104462,"about_ca_topic_score_gemma":0.001396596,"domain_scores_codex":[0.9999396,0.00001372867,0.000003238003,0.00001374832,0.00001787384,0.00001189885],"domain_scores_gemma":[0.9997942,0.0000500661,0.00006842442,0.00001033598,0.00002878451,0.00004816207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004457085,0.0001968478,0.6990594,0.0000631698,0.00008059954,0.0007428213,0.001149582,0.001161357,0.2632026,0.0001010953,0.0002832773,0.02950221],"study_design_scores_gemma":[0.00001780477,0.0006111272,0.9883692,0.00000424121,0.00003575555,0.0005436662,0.0001964462,0.001908662,0.007770688,0.00004810985,0.0004831019,0.00001117028],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995404,0.0001497014,0.0001698112,0.00000690811,0.000001384109,0.000002291978,0.00004004314,0.000002921718,0.00008655607],"genre_scores_gemma":[0.9995701,0.00004694966,0.0001428546,0.000007472804,0.000002468352,0.000004463415,0.0001040455,0.000001083988,0.0001205659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001104462,"threshold_uncertainty_score":0.002196074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009572440020833229,"score_gpt":0.2403329134280272,"score_spread":0.2307604734071939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}