{"id":"W2966919884","doi":"10.3390/cancers11081165","title":"Long-Term Dynamics of Three Dimensional Telomere Profiles in Circulating Tumor Cells in High-Risk Prostate Cancer Patients Undergoing Androgen-Deprivation and Radiation Therapy","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"CancerCare Manitoba Foundation","keywords":"Prostate cancer; Medicine; Telomere; Oncology; Circulating tumor cell; Surrogate endpoint; Internal medicine; Androgen deprivation therapy; Cancer; Radiation therapy; Prostate; Biopsy; Urology; Metastasis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299466,0.0001259393,0.000274861,0.0001518562,0.00002307563,0.000008076533,0.0000326142,0.00004477134,0.00005127945],"category_scores_gemma":[0.0000199054,0.0001158372,0.00003171448,0.0002549743,0.00003585532,0.0001088909,0.00001922127,0.0001266779,9.52497e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001186753,"about_ca_system_score_gemma":0.0004550538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00331511,"about_ca_topic_score_gemma":0.005635368,"domain_scores_codex":[0.9989976,0.00002703894,0.0003249361,0.0002650733,0.0002005242,0.000184798],"domain_scores_gemma":[0.9994477,0.00005930014,0.0002577599,0.0001233576,0.0000636376,0.00004823043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000244195,0.00003101329,0.93529,0.0002573563,0.00002651579,0.000003339141,0.0003242851,0.005121888,0.003940311,0.00001664376,0.000004725781,0.05473977],"study_design_scores_gemma":[0.005418251,0.0001941247,0.9789656,0.0004623429,0.00002260444,0.000001002147,0.00006604191,0.005157519,0.009507389,0.00006318912,0.00001122588,0.0001306506],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970431,0.001540891,0.000008477713,0.00004499235,0.0002371684,0.0009877435,0.0001057753,0.000008703371,0.00002318345],"genre_scores_gemma":[0.9977908,0.001798761,0.0001310006,0.00006435536,0.00002993706,0.00005140966,0.00009333202,0.00002253185,0.00001786742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05460911,"threshold_uncertainty_score":0.5011476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009572440020833229,"score_gpt":0.2403329134280272,"score_spread":0.2307604734071939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}