{"id":"W2966925675","doi":"10.3390/antibiotics8030117","title":"Put a Bow on It: Knotted Antibiotics Take Center Stage","year":2019,"lang":"en","type":"review","venue":"Antibiotics","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"MaRS; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Peptide; Computational biology; Antibiotics; Peptide Biosynthesis; Subclass; Lantibiotics; Biosynthesis; Biology; Protease; Chemistry; Biochemistry; RNA; Genetics; Ribosome; Bacteriocin; Gene; Bacteria; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000299684,0.0008879361,0.002842442,0.0003761049,0.0001005733,0.000101939,0.0003984688,0.001005578,0.0004063183],"category_scores_gemma":[0.0003199974,0.0005931014,0.0009360739,0.0005502691,0.0001354468,0.00005792885,0.0001772429,0.001251184,0.002404126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001662121,"about_ca_system_score_gemma":0.0003968693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001938337,"about_ca_topic_score_gemma":0.000007148218,"domain_scores_codex":[0.9966923,0.000129699,0.0009519072,0.001023388,0.0004716655,0.0007310454],"domain_scores_gemma":[0.9975002,0.0001711133,0.0005470681,0.001396962,0.0001606215,0.0002240297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009387972,0.001126743,0.00007453525,0.08864202,0.001169043,0.0004503712,0.00003776382,3.324141e-7,0.0006665447,0.0004150341,0.1182094,0.7891144],"study_design_scores_gemma":[0.0004664539,0.0003609253,0.00001788073,0.02910277,0.001832872,0.0001367125,0.00001014379,0.000005911858,0.00179638,9.568619e-7,0.9656388,0.0006302212],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002164504,0.9864942,0.000004219426,0.001314669,0.001881294,0.002350974,0.001003387,0.0001503226,0.00658452],"genre_scores_gemma":[0.001380282,0.9641433,0.0004621778,0.001635423,0.001018163,1.060546e-8,0.0008655365,0.0001822437,0.03031285],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8474294,"threshold_uncertainty_score":0.999652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08659867857613816,"score_gpt":0.353875852127744,"score_spread":0.2672771735516059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}