{"id":"W2966925675","doi":"10.3390/antibiotics8030117","title":"Put a Bow on It: Knotted Antibiotics Take Center Stage","year":2019,"lang":"en","type":"review","venue":"Antibiotics","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"MaRS; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Peptide; Computational biology; Antibiotics; Peptide Biosynthesis; Subclass; Lantibiotics; Biosynthesis; Biology; Protease; Chemistry; Biochemistry; RNA; Genetics; Ribosome; Bacteriocin; Gene; Bacteria; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004238773,0.0004834023,0.0007151009,0.001241309,0.0002773363,0.001243506,0.0004815889,0.001222414,0.005270566],"category_scores_gemma":[0.0005559559,0.000173255,0.0003417657,0.001025939,0.0005037462,0.002515033,0.0007330634,0.002162679,0.003451898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003740528,"about_ca_system_score_gemma":0.0006307593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000345717,"about_ca_topic_score_gemma":0.0007619569,"domain_scores_codex":[0.9998366,0.00003148441,0.00001858408,0.00003074886,0.00005957862,0.00002296917],"domain_scores_gemma":[0.9997792,0.0001007774,0.00002931405,0.000008673692,0.00004983969,0.00003227171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009062477,0.00004990548,0.0001746505,0.008346293,0.00004894204,0.0003058679,0.0001467411,0.0002050357,0.004875475,0.01628922,0.06175753,0.9077097],"study_design_scores_gemma":[0.000005563573,0.00005083358,0.0001763598,0.0009806352,0.00001767567,0.0005709018,0.00005036483,0.00003900483,0.0004633416,0.002387239,0.9952506,0.000007499877],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003281858,0.9929203,0.0003995378,0.002212258,0.001038307,0.00000507424,0.00003113686,0.00002738043,0.003037865],"genre_scores_gemma":[0.002858975,0.99007,0.0005482213,0.002028873,0.0008507246,0.000007272581,0.00005158299,0.00001007159,0.003574191],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005270566,"threshold_uncertainty_score":0.01763183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08659867857613816,"score_gpt":0.353875852127744,"score_spread":0.2672771735516059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}