{"id":"W2967037758","doi":"10.1038/s41598-019-48422-8","title":"Distribution and dynamics of mitochondrial DNA methylation in oocytes, embryos and granulosa cells","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Ministère de l'Agriculture, des Pêcheries et de l'Alimentation","funders":"Natural Sciences and Engineering Research Council of Canada; University of Pittsburgh","keywords":"DNA methylation; Oocyte; Biology; Methylation; Epigenetics; Mitochondrial DNA; Andrology; Somatic cell; Embryo; Bisulfite sequencing; Genetics; Gene; Molecular biology; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008602592,0.00006535143,0.00009901592,0.0003558412,0.0001124473,0.0002270743,0.00008460304,0.0001382844,0.0008183577],"category_scores_gemma":[0.0001959602,0.00008267301,0.00007244227,0.0001746071,0.0001519787,0.0001096011,0.0001233402,0.0001356364,0.000249914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001223134,"about_ca_system_score_gemma":0.0001281171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001496755,"about_ca_topic_score_gemma":0.001547901,"domain_scores_codex":[0.9999489,0.000005426678,0.000004114925,0.00002042892,0.00001066535,0.00001045467],"domain_scores_gemma":[0.999913,0.00001503358,0.00002356946,0.000006810491,0.00002034195,0.00002120079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002383063,0.000005373277,0.01072809,0.00003042398,0.00001011352,0.00004047977,0.0001429367,0.00002767001,0.9853069,0.00007920175,0.00002092803,0.003369607],"study_design_scores_gemma":[0.00001535782,0.0003252261,0.6229786,0.00002177385,0.00005927711,0.0004791449,0.0005943992,0.0006276529,0.3704322,0.0002911242,0.004158693,0.00001661703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965229,0.001080105,0.0009632946,0.00002246173,0.000004866569,0.000006801604,0.0005023441,0.0000120838,0.0008851925],"genre_scores_gemma":[0.9954599,0.0007462349,0.001145733,0.000016239,0.000004917195,0.0000174988,0.000696804,0.000007133684,0.00190553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001496755,"threshold_uncertainty_score":0.00297606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004918395973512384,"score_gpt":0.2242304188462196,"score_spread":0.2193120228727073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}