{"id":"W2967055487","doi":"10.1182/blood.v130.suppl_1.813.813","title":"Preliminary Results from a Phase Ib Study Evaluating BCL-2 Inhibitor Venetoclax in Combination with MEK Inhibitor Cobimetinib or MDM2 Inhibitor Idasanutlin in Patients with Relapsed or Refractory (R/R) AML","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Venetoclax; Refractory (planetary science); Medicine; MEK inhibitor; Lenalidomide; Internal medicine; Oncology; Leukemia; Chemistry; Multiple myeloma; Biology; Kinase; Chronic lymphocytic leukemia; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002192274,0.0006756877,0.001166445,0.0007183495,0.0004006318,0.0001941524,0.0005965806,0.000387065,0.00008012126],"category_scores_gemma":[0.004844394,0.0004610744,0.00007654058,0.0007405195,0.0003071867,0.0007379864,0.0004095255,0.001541061,0.0000466167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001271285,"about_ca_system_score_gemma":0.002559484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001576491,"about_ca_topic_score_gemma":0.001776474,"domain_scores_codex":[0.99319,0.0007754549,0.0014998,0.001482062,0.0021259,0.0009268077],"domain_scores_gemma":[0.9950292,0.000940339,0.001046489,0.001891945,0.0006807249,0.0004113583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4869809,0.05478023,0.4125445,0.000344609,0.000663878,0.004688454,0.01303372,0.00003715013,0.008389395,0.000002189855,0.001624241,0.01691072],"study_design_scores_gemma":[0.4084713,0.1176625,0.4565449,0.003313725,0.0005333408,0.00002317752,0.002507272,0.0008895654,0.009085984,0.000009388124,0.000185327,0.0007735069],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915667,0.00007942025,0.000004719436,0.0003060738,0.0002185941,0.007224575,0.0002490328,0.0001215257,0.0002294272],"genre_scores_gemma":[0.995,0.00001672531,0.002354918,0.00007538145,0.0004855781,0.0006465797,0.0006311525,0.0001787636,0.0006109187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07850957,"threshold_uncertainty_score":0.9997841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04089107456193912,"score_gpt":0.3463352910666302,"score_spread":0.3054442165046911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}