{"id":"W2967055487","doi":"10.1182/blood.v130.suppl_1.813.813","title":"Preliminary Results from a Phase Ib Study Evaluating BCL-2 Inhibitor Venetoclax in Combination with MEK Inhibitor Cobimetinib or MDM2 Inhibitor Idasanutlin in Patients with Relapsed or Refractory (R/R) AML","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Venetoclax; Refractory (planetary science); Medicine; MEK inhibitor; Lenalidomide; Internal medicine; Oncology; Leukemia; Chemistry; Multiple myeloma; Biology; Kinase; Chronic lymphocytic leukemia; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001160006,0.0006875625,0.001312756,0.000214325,0.000313516,0.0007454416,0.0005963044,0.0006145291,0.003215452],"category_scores_gemma":[0.0007911462,0.000303167,0.0008213714,0.0003333868,0.0004889714,0.0006289548,0.0002464759,0.002387925,0.0005892694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005543407,"about_ca_system_score_gemma":0.0009705039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009949588,"about_ca_topic_score_gemma":0.00369316,"domain_scores_codex":[0.9997054,0.0001493734,0.00002386422,0.00003743578,0.00002928298,0.00005461704],"domain_scores_gemma":[0.9993031,0.0001786014,0.0001403207,0.00006157337,0.00005002944,0.0002663347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5189098,0.08656744,0.01966147,0.001684897,0.002378362,0.0007481409,0.0006321042,0.004410924,0.1649726,0.0003745784,0.007563908,0.1920958],"study_design_scores_gemma":[0.2163421,0.7177067,0.03811646,0.000088247,0.00123946,0.001052774,0.0001268152,0.001474954,0.01735215,0.0002304716,0.006229809,0.00004009768],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924753,0.002134437,0.0005644961,0.0004488303,0.00005467097,0.001111102,0.001012098,0.00007722426,0.002121777],"genre_scores_gemma":[0.9917724,0.001795394,0.001547811,0.0004362759,0.0000961077,0.0006841378,0.00202391,0.00002453493,0.001619522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003215452,"threshold_uncertainty_score":0.01075679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04089107456193912,"score_gpt":0.3463352910666302,"score_spread":0.3054442165046911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}