{"id":"W2967102081","doi":"10.1093/ecco-jcc/jjz144","title":"Enhanced E. coli LF82 Translocation through the Follicle-associated Epithelium in Crohn’s Disease is Dependent on Long Polar Fimbriae and CEACAM6 expression, and Increases Paracellular Permeability","year":2019,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Vetenskapsrådet; Linköpings Universitet; Region Östergötland; Lions Clubs International Foundation","keywords":"Paracellular transport; Biology; Microbiology; Fimbria; Intestinal epithelium; Ussing chamber; Epithelium; Intestinal mucosa; In vitro; Molecular biology; Escherichia coli; Internal medicine; Permeability (electromagnetism); Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001443973,0.000241588,0.0002612357,0.0002826802,0.0001925671,0.0003176387,0.00008457635,0.0004712912,0.001447029],"category_scores_gemma":[0.0002545833,0.0001647494,0.0002333796,0.0001358002,0.000223243,0.000282602,0.0002345405,0.0004451974,0.0002411571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000187942,"about_ca_system_score_gemma":0.00007970964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002162026,"about_ca_topic_score_gemma":0.000265293,"domain_scores_codex":[0.9998685,0.00002521304,0.00001408897,0.00002933555,0.00003052434,0.00003231888],"domain_scores_gemma":[0.9998323,0.00002736834,0.00005977807,0.00001352352,0.00002152758,0.00004542288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001024031,0.00007792428,0.01402894,0.0001688929,0.00001465705,0.0007085854,0.0000998023,0.00002746752,0.9809269,0.00003904269,0.00007938954,0.002804412],"study_design_scores_gemma":[0.000109183,0.00336229,0.6336,0.00006687402,0.000109889,0.01694308,0.0006293689,0.0008898069,0.339393,0.0002007938,0.004678409,0.00001734884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983643,0.001148616,0.0001721577,0.00004093138,0.000005725088,0.000005586433,0.0000413026,0.000007165292,0.0002141963],"genre_scores_gemma":[0.9987897,0.0004757548,0.0003267711,0.00003566279,0.000007443025,0.000006004298,0.00009361468,0.000002171935,0.0002627826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447029,"threshold_uncertainty_score":0.004840791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006115159032197164,"score_gpt":0.2310097621003508,"score_spread":0.2248946030681537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}