{"id":"W2967102081","doi":"10.1093/ecco-jcc/jjz144","title":"Enhanced E. coli LF82 Translocation through the Follicle-associated Epithelium in Crohn’s Disease is Dependent on Long Polar Fimbriae and CEACAM6 expression, and Increases Paracellular Permeability","year":2019,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Vetenskapsrådet; Linköpings Universitet; Region Östergötland; Lions Clubs International Foundation","keywords":"Paracellular transport; Biology; Microbiology; Fimbria; Intestinal epithelium; Ussing chamber; Epithelium; Intestinal mucosa; In vitro; Molecular biology; Escherichia coli; Internal medicine; Permeability (electromagnetism); Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003640124,0.0001592966,0.0002103506,0.0000322087,0.0001168962,0.00006947446,0.0001030561,0.0001074034,0.00003104085],"category_scores_gemma":[0.0001356875,0.0001207941,0.00007651337,0.00004128233,0.0001163877,0.00003098433,0.00004675813,0.0001401615,0.000001099084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002988844,"about_ca_system_score_gemma":0.0001289665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009793321,"about_ca_topic_score_gemma":0.0001178903,"domain_scores_codex":[0.9987417,0.0002343847,0.0003612041,0.0002491036,0.0002102849,0.0002033038],"domain_scores_gemma":[0.9992053,0.0000483398,0.0002238478,0.0002091046,0.0001372416,0.0001761942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05244241,0.002326783,0.7211397,0.0008995884,0.0005869021,0.001931433,0.00632159,0.0002616872,0.2009506,0.0008833823,0.001649629,0.01060632],"study_design_scores_gemma":[0.001714193,0.0001364017,0.9836951,0.0001534496,0.00004567371,0.000018313,0.0002837252,0.00005630753,0.01298674,0.0005241309,0.0002379272,0.000148048],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962216,0.002772012,0.00009121076,0.0003539486,0.00006116065,0.0003620894,0.00009144724,0.000002841299,0.00004368151],"genre_scores_gemma":[0.9978777,0.001308061,0.00002092006,0.0005705559,0.00006855339,0.0000129213,0.00001179121,0.00001422173,0.0001153201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2625554,"threshold_uncertainty_score":0.492584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006115159032197164,"score_gpt":0.2310097621003508,"score_spread":0.2248946030681537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}