{"id":"W2967149621","doi":"10.1186/s13148-019-0708-z","title":"DNA methylation signature is prognostic of choroid plexus tumor aggressiveness","year":2019,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Princess Margaret Cancer Centre; Montreal Children's Hospital; SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Brain Tumour Charity; Cancer Research UK; Ontario Genomics; Genome Canada","keywords":"dNaM; Choroid plexus papilloma; DNA methylation; Choroid plexus; Epigenetics; Medicine; Biology; Bioinformatics; Pathology; Oncology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002879038,0.000166093,0.0005790481,0.00006260806,0.00002427877,0.000008947499,0.0001041049,0.000200362,0.0003824909],"category_scores_gemma":[0.0006992439,0.0001274398,0.0002631582,0.0001881197,0.00009889286,0.00002200731,0.00005347019,0.0002181868,0.0001737235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000242181,"about_ca_system_score_gemma":0.000121063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007078425,"about_ca_topic_score_gemma":0.000002149267,"domain_scores_codex":[0.9983259,0.0000917803,0.0007041608,0.0003551407,0.0003118645,0.0002111272],"domain_scores_gemma":[0.9979837,0.0007812979,0.0003349433,0.0004784886,0.0002413774,0.0001802089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001395521,0.001292194,0.9741122,0.0001552508,0.0001969995,0.00006653171,0.00006757066,0.00003597504,0.006501548,0.0001609967,0.000434027,0.01683717],"study_design_scores_gemma":[0.002908703,0.001653612,0.910076,0.0003530981,0.0003936851,0.000009332221,0.00002814563,0.0004446179,0.08057913,0.0007221078,0.002677863,0.0001536576],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944102,0.003206868,0.00004673543,0.0004842489,0.0004519007,0.000805017,0.00002897596,0.00002465226,0.0005414459],"genre_scores_gemma":[0.9970961,0.0004348881,0.001526012,0.0005796637,0.0001665015,0.00002377058,0.00003684541,0.00002750665,0.0001087214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07407758,"threshold_uncertainty_score":0.5196844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03530230870936922,"score_gpt":0.3567208028945009,"score_spread":0.3214184941851317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}