{"id":"W2967162008","doi":"10.1016/j.ebiom.2019.07.066","title":"Biodistribution, shedding, and transmissibility of the oncolytic virus talimogene laherparepvec in patients with melanoma","year":2019,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"EMD Serono; Pfizer; Merck Sharp and Dohme; Bristol-Myers Squibb; Amgen","keywords":"Medicine; Oncolytic virus; Herpes simplex virus; Melanoma; Urine; Viral shedding; Oral mucosa; Pathology; Virus; Gastroenterology; Internal medicine; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829957,0.0001083123,0.0001636335,0.00004323847,0.00002657112,0.000003834354,0.0001585084,0.00007537518,0.00007476971],"category_scores_gemma":[0.00002860194,0.00006638376,0.00002900368,0.000223633,0.0002123977,0.000002651433,0.00004854253,0.00007625667,0.000002608124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002833215,"about_ca_system_score_gemma":0.00008896882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006334665,"about_ca_topic_score_gemma":0.0002068238,"domain_scores_codex":[0.9990688,0.00007089106,0.0001939961,0.0002638829,0.0002233783,0.0001790732],"domain_scores_gemma":[0.9993839,0.00001138357,0.00006298983,0.0004027552,0.00007902495,0.00005997823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00172438,0.00016501,0.5860702,0.00004303669,0.00003914763,6.209535e-7,0.00006669908,0.000006230278,0.40961,0.000002915901,0.0001230497,0.002148726],"study_design_scores_gemma":[0.003784209,0.004441253,0.6232163,0.00005088242,0.00001293204,0.000001252787,0.00003136851,0.0000218272,0.3666387,0.00001651501,0.001677902,0.0001069071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998602,0.0004842015,0.00002286289,0.0001963618,0.00004488876,0.0004408629,0.00007511944,0.000003261966,0.0001304409],"genre_scores_gemma":[0.9995915,0.00002945816,0.00002023058,0.0001004894,0.00002674288,0.000007532572,0.0001057549,0.00001016051,0.0001081148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04297129,"threshold_uncertainty_score":0.2707051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004881814466318224,"score_gpt":0.2449822709821757,"score_spread":0.2401004565158575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}