{"id":"W2967224921","doi":"10.1155/2019/5174957","title":"N-Acetyl-L-cysteine Protects Human Retinal Pigment Epithelial Cells from Oxidative Damage: Implications for Age-Related Macular Degeneration","year":2019,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; National Institute on Aging; National Institutes of Health; Foundation Fighting Blindness","keywords":"Oxidative stress; Reactive oxygen species; Glutathione; Macular degeneration; Retinal pigment epithelium; Chemistry; P22phox; NADPH oxidase; Antioxidant; Programmed cell death; Retinal; Biochemistry; Molecular biology; Pharmacology; Biology; Apoptosis; Medicine; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003197577,0.0003941026,0.0006923429,0.0001168406,0.0002697741,0.00002921154,0.0001130675,0.0001487557,0.0004442429],"category_scores_gemma":[0.00008540478,0.0002974851,0.0001662017,0.0002151015,0.0002731567,0.0001032367,0.00007113732,0.00023345,0.00005931272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001228522,"about_ca_system_score_gemma":0.00006674642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00028291,"about_ca_topic_score_gemma":0.00002064626,"domain_scores_codex":[0.9978828,0.0001814899,0.0005034526,0.0007513667,0.0003306039,0.0003502198],"domain_scores_gemma":[0.9984728,0.0001168809,0.0002992579,0.0005300585,0.0002512209,0.0003298552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003685046,0.0003492262,0.006816681,0.0001882296,0.00034065,0.00005336947,0.0004816881,0.000003427073,0.9875495,0.001823375,0.0003568795,0.001668418],"study_design_scores_gemma":[0.01675287,0.009762798,0.1032124,0.0008495471,0.002222464,0.00002114636,0.0007437822,0.0004944108,0.8553476,0.004375647,0.005498425,0.0007189228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874656,0.0009926782,0.00420073,0.002020801,0.0001322932,0.003732939,0.0002707026,0.00004990766,0.001134322],"genre_scores_gemma":[0.9930325,0.0001158879,0.001185714,0.0002272817,0.0002805299,0.0003060499,0.00282269,0.00004698751,0.001982398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.132202,"threshold_uncertainty_score":0.9999477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756751316349806,"score_gpt":0.2964497515977534,"score_spread":0.2688822384342554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}