{"id":"W2967232987","doi":"10.1182/blood.v130.suppl_1.87.87","title":"Phase 1/2 Trial of Subcutaneously Administered Factor IX Variant CB2679d/ISU304: Pharmacokinetics and Activity","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pharmacokinetics; Potency; Factor IX; Pharmacology; In vivo; Medicine; Antigen; Bioavailability; Clotting factor; Antibody; Chemistry; In vitro; Immunology; Internal medicine; Biology; Biochemistry; Biotechnology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007745225,0.001334701,0.00118453,0.0003148747,0.0003135901,0.000795125,0.0005466304,0.0009789836,0.004405566],"category_scores_gemma":[0.0004587784,0.0003153855,0.0007326814,0.000252736,0.0006823911,0.0005013728,0.0002282665,0.002317588,0.0007847606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008810175,"about_ca_system_score_gemma":0.00113654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008959285,"about_ca_topic_score_gemma":0.001497732,"domain_scores_codex":[0.9997688,0.00006262529,0.000007826582,0.00004919314,0.0000372135,0.00007430925],"domain_scores_gemma":[0.9997539,0.00002742642,0.00004549848,0.00001908129,0.00002630635,0.0001277645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6973459,0.09629463,0.003597298,0.0007972294,0.0009876394,0.0005070578,0.0002048378,0.00337327,0.1012419,0.001074185,0.01211761,0.0824584],"study_design_scores_gemma":[0.3251987,0.6483795,0.005774516,0.00004017111,0.000319229,0.0004109856,0.00004885541,0.002512391,0.01288871,0.0004046436,0.003988419,0.00003390744],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929483,0.0009973702,0.0005793312,0.0003320782,0.0001317974,0.001910858,0.0009544255,0.0001160754,0.00202996],"genre_scores_gemma":[0.9887792,0.000746155,0.001092767,0.0004584533,0.000130778,0.00163716,0.002020171,0.00003150766,0.005103802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004405566,"threshold_uncertainty_score":0.01473808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08010780582738142,"score_gpt":0.396971835392356,"score_spread":0.3168640295649746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}