{"id":"W2967245728","doi":"","title":"Engineering Red Blood Cell Progenitors to Achieve Greater Proliferative Potential","year":2015,"lang":"en","type":"dissertation","venue":"TSpace (University of Toronto)","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; University of Pennsylvania","keywords":"Progenitor cell; Erythropoietin; Stem cell; Biology; Ectopic expression; Erythropoiesis; Cell biology; Stem cell factor; Bone marrow; Molecular biology; Transcription factor; Doxycycline; Immunology; Transferrin receptor; Cell; Cell culture; Gene; Medicine; Genetics; Internal medicine; Anemia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006374675,0.0002365066,0.000481754,0.00009093574,0.00006740403,0.000005162639,0.0001191986,0.0003374266,0.00382363],"category_scores_gemma":[0.00001737553,0.0002706617,0.0001691332,0.000065241,0.00002032817,0.0001080817,0.00003743462,0.0002107537,0.00007083421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916781,"about_ca_system_score_gemma":0.0002120237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003982483,"about_ca_topic_score_gemma":0.0028214,"domain_scores_codex":[0.9990494,0.00003814452,0.0001055327,0.0003461387,0.0002465736,0.0002142616],"domain_scores_gemma":[0.9990117,0.000007784473,0.0001384549,0.0002505539,0.0003433367,0.0002481508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03355987,0.001456019,0.001074889,0.003327401,0.002441767,0.001078584,0.1500947,0.0004663584,0.7660632,0.00006670518,0.02862338,0.01174712],"study_design_scores_gemma":[0.02915206,0.02515409,0.6394011,0.00213269,0.01065604,0.0002550418,0.1918889,0.001677198,0.07547247,0.00003028324,0.0200002,0.004179989],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599054,0.0002000003,0.00006434426,0.0002602221,0.0008181166,0.0007427628,0.00002273864,0.00009104926,0.03789531],"genre_scores_gemma":[0.9144055,0.00006564652,0.002702037,0.00003058604,0.0002892544,0.000002187474,0.0005655218,0.00003969411,0.08189959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6905907,"threshold_uncertainty_score":0.9999745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076809045596025,"score_gpt":0.2338922842788037,"score_spread":0.2231241938228435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}