{"id":"W2967367406","doi":"10.1038/s41523-019-0115-9","title":"Homologous recombination DNA repair defects in PALB2-associated breast cancers","year":2019,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; McGill Genome Centre; Jewish General Hospital","funders":"National Cancer Institute; Medical Research Council; National Health and Medical Research Council; Ministerstvo Zdravotnictví Ceské Republiky; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Cycle for Survival; National Breast Cancer Foundation; National Institute for Health and Care Research; China Scholarship Council; Susan G. Komen; Univerzita Karlova v Praze; Ministry of Higher Education, Malaysia; NIHR Cambridge Biomedical Research Centre; European Commission; Breast Cancer Research Foundation; Cancer Australia; National Science Foundation","keywords":"PALB2; Genetics; Biology; Allele; Breast cancer; Germline mutation; Germline; Homologous recombination; Mutation; Gene; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777872,0.0002327197,0.0001461837,0.0007868175,0.000200117,0.000281922,0.0001408,0.0002128965,0.002363007],"category_scores_gemma":[0.0003748875,0.0001004233,0.0001630327,0.0005102781,0.000193508,0.0001260019,0.0003306971,0.0001402948,0.0002935457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113704,"about_ca_system_score_gemma":0.00007018985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003492351,"about_ca_topic_score_gemma":0.0005020253,"domain_scores_codex":[0.9998528,0.00001963651,0.00001524482,0.0000485708,0.00004116635,0.00002264185],"domain_scores_gemma":[0.9997815,0.00003778362,0.00009629485,0.00002144162,0.00002281913,0.00004012184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008271218,0.0000677516,0.5893519,0.0001068998,0.0001206539,0.006478881,0.0002074766,0.0002760252,0.390223,0.0001665594,0.0002350174,0.01193873],"study_design_scores_gemma":[0.00002767205,0.0001716673,0.931516,0.00001443079,0.00005700784,0.03848997,0.0002161226,0.0008543551,0.02727227,0.0002177861,0.001154394,0.000008336427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986517,0.000290621,0.000367625,0.00001159437,0.000001837703,0.000005522753,0.0001877353,0.00001449375,0.0004689897],"genre_scores_gemma":[0.9994429,0.00006474629,0.0001877128,0.00001195355,0.000002464536,0.000003901298,0.0001512411,0.000003842858,0.0001311597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002363007,"threshold_uncertainty_score":0.007905006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00452957797043336,"score_gpt":0.2255653187493903,"score_spread":0.221035740778957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}