{"id":"W2967404030","doi":"10.1186/s12916-019-1400-z","title":"New approaches for detecting cancer with circulating cell-free DNA","year":2019,"lang":"en","type":"letter","venue":"BMC Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Mount Sinai Hospital","funders":"","keywords":"Medicine; Cell-free fetal DNA; Circulating tumor DNA; Biomarker; Cancer; Cancer detection; Liquid biopsy; DNA; Oncology; Internal medicine; Computational biology; Cancer research; Bioinformatics; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002688781,0.0007699197,0.0007399935,0.0009594529,0.0009124533,0.001815175,0.001223225,0.008098368,0.00487227],"category_scores_gemma":[0.007756065,0.0003359378,0.0008584936,0.0005052933,0.002992277,0.002813763,0.001102569,0.01293595,0.005301636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001987991,"about_ca_system_score_gemma":0.0007192348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003471301,"about_ca_topic_score_gemma":0.0005232757,"domain_scores_codex":[0.9981287,0.0005964763,0.0001312076,0.0002682424,0.0007408995,0.0001344056],"domain_scores_gemma":[0.9963564,0.002631796,0.0001846387,0.0001907485,0.0004162628,0.0002201357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005459641,0.000395933,0.002538312,0.003239118,0.0001498915,0.01974621,0.0004857109,0.0004837836,0.02331877,0.07625796,0.4604085,0.4124298],"study_design_scores_gemma":[0.0001892415,0.0003447097,0.0008743034,0.0008094348,0.00006650784,0.02363195,0.0002357598,0.0009338719,0.006599771,0.04741369,0.9188366,0.00006416145],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003743295,0.2630124,0.02201593,0.644442,0.0429799,0.0002201836,0.0001079796,0.0003578613,0.02312048],"genre_scores_gemma":[0.0573223,0.2356225,0.031994,0.5091287,0.1409157,0.0007256854,0.0002096096,0.0001472799,0.02393425],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.008098368,"threshold_uncertainty_score":0.01629937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04109146039287472,"score_gpt":0.2522831233557769,"score_spread":0.2111916629629021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}