{"id":"W2967414383","doi":"10.1016/j.celrep.2019.07.032","title":"m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; Simon Fraser University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Stand Up To Cancer; Weill Cornell Medical College; National Heart and Lung Institute; New York State Stem Cell Science; National Institutes of Health; Pershing Square Sohn Cancer Research Alliance; Leukemia and Lymphoma Research; Alex's Lemonade Stand Foundation for Childhood Cancer; Leukemia and Lymphoma Society; American Society of Hematology; Burroughs Wellcome Fund","keywords":"Stem cell; Haematopoiesis; Hematopoietic stem cell; RNA; Methylation; Biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527073,0.0001887357,0.000145817,0.0003807746,0.0002475834,0.0003318318,0.0002611268,0.0002335982,0.0013352],"category_scores_gemma":[0.000190393,0.0001710364,0.0001356797,0.0001268837,0.0003319776,0.0001551604,0.0002713776,0.0004172368,0.0006685517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002915301,"about_ca_system_score_gemma":0.0002387094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006123876,"about_ca_topic_score_gemma":0.001395705,"domain_scores_codex":[0.9998348,0.00002581872,0.00001435642,0.00004272136,0.00004326529,0.00003905593],"domain_scores_gemma":[0.9997297,0.00003461417,0.00008275703,0.00005232414,0.00002605161,0.00007456886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003663116,0.000005895764,0.0002642446,0.000004541167,0.000001343849,0.00001383208,0.000006350854,0.00003106629,0.9986597,0.0001413777,0.00001534588,0.0008196703],"study_design_scores_gemma":[0.000007340001,0.00008094428,0.005549257,0.000002212671,0.000005203768,0.0001031113,0.00001742116,0.000782527,0.9923889,0.0001294637,0.0009306324,0.000003049519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939913,0.0002953517,0.003141145,0.00005381955,0.00001165,0.00001313011,0.0002529512,0.0001281662,0.002112473],"genre_scores_gemma":[0.9970669,0.00009397148,0.001251619,0.00001677929,0.00000413009,0.000008560268,0.0001887303,0.00002733141,0.001341905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0013352,"threshold_uncertainty_score":0.004466712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220703447214173,"score_gpt":0.24926666804745,"score_spread":0.2370596335753083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}