{"id":"W2967422202","doi":"10.1016/j.celrep.2019.07.035","title":"TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; BC Children's Hospital; Canadian Diabetes Association","keywords":"PDX1; Progenitor cell; Pancreas; Biology; Cell biology; Progenitor; Endocrine system; Cellular differentiation; Activator (genetics); Methylation; DNA methylation; Stem cell; Gene expression; Internal medicine; Endocrinology; Gene; Transcription factor; Genetics; Hormone; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445148,0.0001356723,0.0003029465,0.00009088707,0.00003560211,0.00002888091,0.00001730578,0.00006706802,0.00005534269],"category_scores_gemma":[0.00008839382,0.0001159806,0.00003069388,0.00009676527,0.00004729334,0.00009459892,0.00001944834,0.00009356155,0.00002120583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006079071,"about_ca_system_score_gemma":0.00004579712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000796986,"about_ca_topic_score_gemma":0.00001747381,"domain_scores_codex":[0.9990562,0.00001925433,0.0002593811,0.0003465177,0.0001628762,0.0001558332],"domain_scores_gemma":[0.9992934,0.00007892522,0.000177485,0.0002929297,0.00003595047,0.0001213115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000770168,0.0001546632,0.8632259,0.0002081595,0.00001568857,0.00003742586,0.000151633,6.610711e-7,0.1337753,0.000004208061,0.0001635688,0.002185736],"study_design_scores_gemma":[0.0008179125,0.00007449142,0.9564652,0.00006647041,0.00007916214,0.0000780869,0.00006328504,0.001140065,0.04069386,0.00004156812,0.0003661616,0.0001137342],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946458,0.0001690055,0.00004478237,0.00006638443,0.0001232619,0.0005981748,0.000004233407,0.00003019728,0.004318143],"genre_scores_gemma":[0.9984186,0.00001943701,0.000064876,0.00002030902,0.00006822615,0.00002435884,0.0001690904,0.00001458122,0.001200493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09323925,"threshold_uncertainty_score":0.4729551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0153468911009042,"score_gpt":0.2353883519670121,"score_spread":0.2200414608661079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}