{"id":"W2967422202","doi":"10.1016/j.celrep.2019.07.035","title":"TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; BC Children's Hospital; Canadian Diabetes Association","keywords":"PDX1; Progenitor cell; Pancreas; Biology; Cell biology; Progenitor; Endocrine system; Cellular differentiation; Activator (genetics); Methylation; DNA methylation; Stem cell; Gene expression; Internal medicine; Endocrinology; Gene; Transcription factor; Genetics; Hormone; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082789,0.0003011562,0.000252299,0.0003141374,0.0001658092,0.0006669085,0.0002898144,0.0002432616,0.001390975],"category_scores_gemma":[0.0001534358,0.0001771619,0.0002845744,0.000190056,0.0002977767,0.0004226154,0.0003154507,0.0004353421,0.0003642967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004173197,"about_ca_system_score_gemma":0.0003517059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008875921,"about_ca_topic_score_gemma":0.001386624,"domain_scores_codex":[0.9998603,0.00001612697,0.00001519129,0.00003933668,0.0000300878,0.00003903678],"domain_scores_gemma":[0.9998945,0.00001606956,0.00002038976,0.00001692119,0.00001333583,0.00003878769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001484955,0.0000158301,0.002262044,0.0000298878,0.000007494701,0.00007564718,0.00003418757,0.00002768018,0.9937057,0.0003932851,0.0000306501,0.003269096],"study_design_scores_gemma":[0.00001921319,0.0001384501,0.05434395,0.000008100917,0.00003612151,0.000538623,0.00009795593,0.0007743636,0.9411064,0.0001790184,0.002746281,0.00001155599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891548,0.00447868,0.003400628,0.00005747347,0.00002525587,0.00002429902,0.0003049095,0.0001114077,0.00244263],"genre_scores_gemma":[0.9918672,0.001113833,0.001794723,0.00003643124,0.000006505998,0.00001985365,0.0005955946,0.0000295254,0.004536313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390975,"threshold_uncertainty_score":0.004653215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0153468911009042,"score_gpt":0.2353883519670121,"score_spread":0.2200414608661079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}