{"id":"W2967655643","doi":"10.1002/cbic.201900455","title":"An Unintentional Discovery of a Fluorogenic DNA Probe for Ribonuclease I","year":2019,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"RNase P; Ribonuclease; Enterobacter aerogenes; Escherichia coli; Biology; Bacteria; Molecular probe; Hybridization probe; Biochemistry; RNase H; Computational biology; Chemistry; DNA; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005175963,0.0006171027,0.0003629593,0.0004277385,0.0001999139,0.0003296527,0.0005939397,0.001238742,0.0005469666],"category_scores_gemma":[0.000820143,0.0002284779,0.0004085205,0.0002859165,0.0004704005,0.0003136966,0.000452018,0.0008118458,0.0005000293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004305955,"about_ca_system_score_gemma":0.000346083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002938198,"about_ca_topic_score_gemma":0.0004313863,"domain_scores_codex":[0.9994224,0.0001025988,0.00001583744,0.0001677522,0.0001666947,0.0001247415],"domain_scores_gemma":[0.9995709,0.0001461243,0.0001158022,0.0000475475,0.00006677373,0.00005280817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002598287,0.00001055112,0.00009595459,0.00003011394,0.000002687745,0.0000588778,0.00001566532,0.00004578984,0.9979337,0.000173534,0.00004282467,0.001564343],"study_design_scores_gemma":[0.000002467891,0.00008700968,0.0002023943,0.000003343301,0.00000368771,0.000137599,0.000006838322,0.0002569859,0.9982668,0.00004378841,0.0009852068,0.0000038502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7696685,0.004534818,0.2178523,0.001024422,0.0002357816,0.0001839635,0.0007539675,0.0006697898,0.005076532],"genre_scores_gemma":[0.8911415,0.00217531,0.1003162,0.0005971917,0.00004440171,0.0001737699,0.0007539308,0.00009571078,0.004701956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238742,"threshold_uncertainty_score":0.003124237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007080345227841193,"score_gpt":0.2621410078936596,"score_spread":0.2550606626658184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}