{"id":"W2967655643","doi":"10.1002/cbic.201900455","title":"An Unintentional Discovery of a Fluorogenic DNA Probe for Ribonuclease I","year":2019,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"RNase P; Ribonuclease; Enterobacter aerogenes; Escherichia coli; Biology; Bacteria; Molecular probe; Hybridization probe; Biochemistry; RNase H; Computational biology; Chemistry; DNA; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152173,0.0001342819,0.0001672396,0.00003401797,0.00002855292,0.00001507112,0.0001662744,0.0001296843,0.000003704575],"category_scores_gemma":[0.0000384297,0.0001206227,0.0002104815,0.00007707668,0.00008411232,0.000008580642,0.00005105228,0.00003954774,0.000002300901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001144122,"about_ca_system_score_gemma":0.0000485286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002367006,"about_ca_topic_score_gemma":0.000001891272,"domain_scores_codex":[0.9991755,0.00001330765,0.000192608,0.0003534667,0.00009524306,0.0001699063],"domain_scores_gemma":[0.9992514,0.000006391165,0.0001137107,0.0004221125,0.0001568229,0.000049605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001381571,0.0001334795,0.0005908824,0.00004059226,0.00006081864,2.484365e-7,0.000005454147,9.520317e-7,0.9976731,0.0003245127,0.0002811896,0.0007506356],"study_design_scores_gemma":[0.0003896194,0.0003480883,0.0002840543,0.00001923356,0.00003511258,0.000006825804,0.00005326778,0.00008861043,0.9964067,0.0002589289,0.001941091,0.0001684528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934225,0.0001483582,0.005763262,0.00004392627,0.00003894784,0.0002540613,0.00007041518,0.00002503465,0.0002335075],"genre_scores_gemma":[0.9898837,0.00002324035,0.008054533,0.00009821415,0.00009757934,0.00001506274,0.0005957314,0.00002221911,0.001209669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003538737,"threshold_uncertainty_score":0.491885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007080345227841193,"score_gpt":0.2621410078936596,"score_spread":0.2550606626658184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}