{"id":"W2967696137","doi":"10.1002/mgg3.929","title":"<i>AMBN</i> mutations causing hypoplastic amelogenesis imperfecta and <i>Ambn</i> knockout‐NLS‐lacZ knockin mice exhibiting failed amelogenesis and <i>Ambn</i> tissue‐specificity","year":2019,"lang":"en","type":"article","venue":"Molecular Genetics & Genomic Medicine","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; National Institute of Dental and Craniofacial Research; National Taiwan University Hospital; McGill University; National Research Foundation of Korea; National Taiwan University; National Research Foundation; Ministry of Science and Technology, Taiwan","keywords":"Ameloblast; Amelogenin; Amelogenesis imperfecta; Amelogenesis; Enamel paint; Enamel organ; Knockout mouse; Cell biology; Dentin; Chemistry; Dental follicle; Molar; Anatomy; Molecular biology; Endocrinology; Internal medicine; Biology; Pathology; Medicine; Dentistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005800618,0.0008603418,0.00150743,0.0004054889,0.0003928865,0.00008033254,0.0001918235,0.0003382187,0.0001659333],"category_scores_gemma":[0.0002543379,0.0007998326,0.0001539287,0.0005846691,0.0006990053,0.00009632758,0.0005143828,0.0004698921,0.0001199248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001595184,"about_ca_system_score_gemma":0.0001662803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000424927,"about_ca_topic_score_gemma":0.00009969965,"domain_scores_codex":[0.9954582,0.0002187612,0.001162313,0.001432164,0.0007421357,0.0009864282],"domain_scores_gemma":[0.9974402,0.0003714519,0.0004077237,0.0008661841,0.0003021933,0.0006122817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002119084,0.00009368873,0.01701935,0.0004109947,0.0003299207,0.0003745224,0.001081222,0.00009812041,0.9702454,0.0000580076,0.000459571,0.009617253],"study_design_scores_gemma":[0.01635933,0.003567797,0.07965899,0.001667854,0.003822971,0.003446669,0.006452991,0.001992246,0.8647273,0.0008115351,0.01457423,0.002918067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.949387,0.04205286,0.003129286,0.001321119,0.0004453231,0.001942069,0.00004972375,0.0001381942,0.001534459],"genre_scores_gemma":[0.9884531,0.003556944,0.003827085,0.002630346,0.0004567148,0.00008693351,0.0001151972,0.0001909416,0.0006826697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1055181,"threshold_uncertainty_score":0.9994453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009891027180324191,"score_gpt":0.2452413126219512,"score_spread":0.235350285441627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}