{"id":"W2967696137","doi":"10.1002/mgg3.929","title":"<i>AMBN</i> mutations causing hypoplastic amelogenesis imperfecta and <i>Ambn</i> knockout‐NLS‐lacZ knockin mice exhibiting failed amelogenesis and <i>Ambn</i> tissue‐specificity","year":2019,"lang":"en","type":"article","venue":"Molecular Genetics & Genomic Medicine","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; National Institute of Dental and Craniofacial Research; National Taiwan University Hospital; McGill University; National Research Foundation of Korea; National Taiwan University; National Research Foundation; Ministry of Science and Technology, Taiwan","keywords":"Ameloblast; Amelogenin; Amelogenesis imperfecta; Amelogenesis; Enamel paint; Enamel organ; Knockout mouse; Cell biology; Dentin; Chemistry; Dental follicle; Molar; Anatomy; Molecular biology; Endocrinology; Internal medicine; Biology; Pathology; Medicine; Dentistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002526546,0.0009913987,0.0003907828,0.0008808018,0.0004003934,0.0003743735,0.0004701198,0.000751359,0.003479593],"category_scores_gemma":[0.0001568562,0.0004411835,0.000478606,0.0002407303,0.0007881821,0.0001891412,0.0004413612,0.000818353,0.000964544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004246018,"about_ca_system_score_gemma":0.000268542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001402884,"about_ca_topic_score_gemma":0.001971561,"domain_scores_codex":[0.9996136,0.00004492927,0.00006987243,0.0001028634,0.0001059994,0.00006273139],"domain_scores_gemma":[0.9995876,0.00004705821,0.0002040158,0.00002406985,0.00001791401,0.0001194286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001498224,0.00005923707,0.00046264,0.00003889373,0.00001722091,0.0008106448,0.00003226,0.0001100437,0.99728,0.0001976528,0.0001180232,0.0007235399],"study_design_scores_gemma":[0.0002280932,0.0006026341,0.03854657,0.0000639459,0.0001839891,0.01723931,0.0001655334,0.004764508,0.9263031,0.0002810195,0.01157039,0.00005077915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909792,0.0005032909,0.003577848,0.0001495396,0.00004825346,0.00008431185,0.001938879,0.0002717478,0.002447065],"genre_scores_gemma":[0.986753,0.0004172629,0.005416585,0.0001065421,0.00003269191,0.00009855076,0.001884521,0.0001989176,0.005091976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003479593,"threshold_uncertainty_score":0.01164043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009891027180324191,"score_gpt":0.2452413126219512,"score_spread":0.235350285441627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}