{"id":"W2967805009","doi":"10.1371/journal.pone.0220984","title":"Hsp70 and DNAJA2 limit CFTR levels through degradation","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Ubiquitin ligase; Endoplasmic reticulum; Hsp70; Cystic fibrosis transmembrane conductance regulator; Endoplasmic-reticulum-associated protein degradation; Cell biology; Ubiquitin; Chemistry; Chaperone (clinical); Hsp90; Proteostasis; Protein folding; Cystic fibrosis; Protein degradation; Unfolded protein response; Biochemistry; Biology; Heat shock protein; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001619161,0.0002741709,0.0003967102,0.0001973449,0.0001173497,0.0004209553,0.0001677679,0.0003123099,0.001432556],"category_scores_gemma":[0.0001384388,0.000157221,0.0002583003,0.0001226169,0.0002700643,0.0002891898,0.0003113075,0.0006281605,0.0004091189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002598595,"about_ca_system_score_gemma":0.0002371753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002313469,"about_ca_topic_score_gemma":0.0005072199,"domain_scores_codex":[0.9998499,0.00002470251,0.00001399793,0.00003368581,0.00004166603,0.00003601505],"domain_scores_gemma":[0.9999,0.00001078813,0.00002642783,0.000008645818,0.00001462817,0.00003944256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002184207,0.00002252295,0.0001196322,0.00006054937,0.000008668067,0.00002324842,0.000009501442,0.00007596418,0.9970898,0.0001945354,0.00008543367,0.00209173],"study_design_scores_gemma":[0.00002816059,0.000357381,0.001988135,0.000007836246,0.00001562456,0.0002261465,0.0000201958,0.000523276,0.9926662,0.00009389817,0.004067779,0.000005400097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819819,0.01060065,0.003605962,0.0004861758,0.00009010758,0.00003535664,0.000544394,0.0002216322,0.002433741],"genre_scores_gemma":[0.9925775,0.002143352,0.001702509,0.0001176315,0.000020567,0.00003091598,0.0003928277,0.00002544059,0.002989183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432556,"threshold_uncertainty_score":0.004792392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09756824201302407,"score_gpt":0.3050141856217957,"score_spread":0.2074459436087717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}