{"id":"W2967807085","doi":"10.1016/j.neuron.2019.07.010","title":"A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ","year":2019,"lang":"en","type":"article","venue":"Neuron","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":332,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; EMBO; Georgia Clinical and Translational Science Alliance; Natural Sciences and Engineering Research Council of Canada; Rockefeller University; Ellison Medical Foundation; New York State Department of Health; National Institute of General Medical Sciences; Cure Alzheimer's Fund; New York Stem Cell Foundation","keywords":"PSEN1; Presenilin; Induced pluripotent stem cell; Amyloid precursor protein; Biology; CRISPR; Mutant; Endosome; Phenotype; Genome editing; Genetics; Cell biology; Alzheimer's disease; Gene; Cell; Medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03109143208145631,"score_gpt":0.2889758060988625,"score_spread":0.2578843740174062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."},"direct_labels":[],"classifier":{"requested":true,"available":true,"version":"metacan-v1-d91a1de5be90","frame_rows_covered":4299418,"decision_targets":["metaresearch","metaepi_narrow","metaepi_broad","bibliometrics","sts","scholarly_communication","open_science","research_integrity","randomized_trial","nonrandomized_trial","observational","systematic_review","meta_analysis","case_report","qualitative","simulation_or_modeling","bench_or_experimental","theoretical_or_conceptual","not_applicable"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame.","warning":null},"prediction":{"classifier_version":"metacan-v1-d91a1de5be90","candidate_union":["observational","bench_or_experimental"],"consensus_intersection":["observational","bench_or_experimental"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"scores":{"codex":{"metaresearch":0.006378271152819104,"metaepi_narrow":0.000030518043793392844,"metaepi_broad":0.00006103608758678569,"bibliometrics":0.00009155413138017853,"sts":0.000686655985351339,"scholarly_communication":0.0009613183794918746,"open_science":0.0006256198977645533,"research_integrity":0.00025940337224383917,"randomized_trial":0.00030518043793392844,"nonrandomized_trial":0.00012207217517357137,"observational":0.4395819028000305,"systematic_review":0.000030518043793392844,"meta_analysis":0.0015411612115663385,"case_report":0.00038147554741741054,"qualitative":0.00012207217517357137,"simulation_or_modeling":0.000015259021896696422,"bench_or_experimental":0.9467002365148394,"theoretical_or_conceptual":0.0009002822919050889,"not_applicable":0.0024414435034714275,"design_other":0.00006103608758678569},"gemma":{"metaresearch":0.007797360189211872,"metaepi_narrow":0.000015259021896696422,"metaepi_broad":0.00006103608758678569,"bibliometrics":0.00018310826276035706,"sts":0.0003356984817273213,"scholarly_communication":0.000045777065690089265,"open_science":0.000503547722590982,"research_integrity":0.0007019150072480354,"randomized_trial":0.0010681315327687496,"nonrandomized_trial":0.00019836728465705348,"observational":0.704600595101854,"systematic_review":0.00009155413138017853,"meta_analysis":0.003219653620202945,"case_report":0.000976577401388571,"qualitative":0.00016784924086366064,"simulation_or_modeling":0.00006103608758678569,"bench_or_experimental":0.1680781261921111,"theoretical_or_conceptual":0.0003509575036240177,"not_applicable":0.00019836728465705348}},"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame."}}