{"id":"W2967807085","doi":"10.1016/j.neuron.2019.07.010","title":"A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ","year":2019,"lang":"en","type":"article","venue":"Neuron","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":332,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; EMBO; Georgia Clinical and Translational Science Alliance; Natural Sciences and Engineering Research Council of Canada; Rockefeller University; Ellison Medical Foundation; New York State Department of Health; National Institute of General Medical Sciences; Cure Alzheimer's Fund; New York Stem Cell Foundation","keywords":"PSEN1; Presenilin; Induced pluripotent stem cell; Amyloid precursor protein; Biology; CRISPR; Mutant; Endosome; Phenotype; Genome editing; Genetics; Cell biology; Alzheimer's disease; Gene; Cell; Medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002791782,0.0006668656,0.0004084319,0.0008824638,0.0003710072,0.00043561,0.0003038061,0.0003959511,0.003153179],"category_scores_gemma":[0.0001902335,0.0001406144,0.0005615962,0.0005560422,0.0002263392,0.0001971371,0.000418218,0.0009839705,0.0007438631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002600612,"about_ca_system_score_gemma":0.0002090411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001223335,"about_ca_topic_score_gemma":0.001997188,"domain_scores_codex":[0.9997502,0.00001806852,0.00004697814,0.0000597502,0.00007906336,0.00004601813],"domain_scores_gemma":[0.9998633,0.00003847478,0.00001615075,0.00003086094,0.00002511507,0.00002600165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001482413,0.00005871705,0.0003000523,0.00002302403,0.00002046275,0.000227788,0.00003411664,0.0001016437,0.9971064,0.0001103338,0.0001549025,0.001714374],"study_design_scores_gemma":[0.00003889406,0.0003379267,0.01766739,0.00002268686,0.0001747648,0.002322557,0.0001372704,0.0008756048,0.9712161,0.0002198604,0.00696919,0.0000178566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768594,0.001151392,0.006438619,0.000208251,0.00007203512,0.0001370119,0.007236898,0.0001549666,0.007741408],"genre_scores_gemma":[0.9691924,0.001923313,0.005658583,0.0003870522,0.00002027163,0.0002177262,0.01437727,0.0001544876,0.008068965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003153179,"threshold_uncertainty_score":0.01054841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03109143208145631,"score_gpt":0.2889758060988625,"score_spread":0.2578843740174062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}