{"id":"W2967858406","doi":"10.3390/inorganics7080099","title":"Preliminary Characterization of a Ni2+-Activated and Mycothiol-Dependent Glyoxalase I Enzyme from Streptomyces coelicolor","year":2019,"lang":"en","type":"article","venue":"Inorganics","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo; McMaster University","keywords":"Lactoylglutathione lyase; Streptomyces coelicolor; Glutathione; Biochemistry; Enzyme; Intracellular; Methylglyoxal; Leishmania; Cysteine; Corynebacterium glutamicum; Thiol; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007223157,0.0001057076,0.0001227442,0.00003486641,0.00002799257,0.00001323576,0.0001288853,0.0001179155,0.0001374669],"category_scores_gemma":[0.00009582529,0.0001045525,0.00001836266,0.00009298544,0.00003786863,0.00001269519,0.0001439943,0.00008667841,0.00002334181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001262004,"about_ca_system_score_gemma":0.00007072947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001844212,"about_ca_topic_score_gemma":0.000002714345,"domain_scores_codex":[0.999171,0.00005138561,0.0001790628,0.0003226768,0.0001427798,0.0001331103],"domain_scores_gemma":[0.9993308,0.0000221851,0.0001191355,0.0003293433,0.0001451534,0.0000533775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002125952,0.00004351594,0.004797775,0.00002572933,0.00003135294,8.017178e-7,0.0001089951,0.00001237907,0.9924039,0.00001806521,0.00002995816,0.002314901],"study_design_scores_gemma":[0.0004377062,0.0003859157,0.01232109,0.00001228023,0.000007654039,0.000004163788,0.00006729741,0.0000915845,0.9815395,0.00003312856,0.004987793,0.0001119225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985315,0.0002235828,0.0005590901,0.0001184808,0.00007960505,0.0002721096,0.0001263617,0.00001331697,0.00007600313],"genre_scores_gemma":[0.997907,0.0003349803,0.0003716663,0.00006972744,0.00008041741,0.000008395898,0.0005978867,0.00002226175,0.0006077052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01086447,"threshold_uncertainty_score":0.4263526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007785513051774971,"score_gpt":0.2487014008215802,"score_spread":0.2409158877698052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}