{"id":"W2967876588","doi":"10.1161/atvb.39.suppl_1.114","title":"Abstract 114: Apolipoprotein(a) Secretion is Modulated by Sortilin, Proprotein Convertase Subtilisin/Kexin Type 9, and Microsomal Triglyceride Transfer Protein","year":2019,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"Kexin; Proprotein convertase; Microsomal triglyceride transfer protein; Subtilisin; Secretion; Apolipoprotein B; PCSK9; Apolipoprotein C2; Cholesterylester transfer protein; Triglyceride; Chemistry; Endocrinology; Biochemistry; Internal medicine; Biology; LDL receptor; Lipoprotein; Very low-density lipoprotein; Medicine; Cholesterol; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007025588,0.0002173185,0.0002005503,0.0001061841,0.0001353671,0.0003626093,0.0001191081,0.000208036,0.001860348],"category_scores_gemma":[0.00005892342,0.0000855764,0.0002281686,0.0001942946,0.0001237398,0.0001500268,0.0001087401,0.0003282527,0.001036715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002375773,"about_ca_system_score_gemma":0.0001531509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007532031,"about_ca_topic_score_gemma":0.0005618725,"domain_scores_codex":[0.9999216,0.00001112057,0.00001164654,0.00001441936,0.00002288654,0.00001836328],"domain_scores_gemma":[0.9999459,0.00000820796,0.00001380064,0.000006175589,0.000009614801,0.00001630419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002841739,0.00001924832,0.0003331997,0.00003797229,0.000005574142,0.0001217353,0.000008321644,0.00001773935,0.9981372,0.00003712908,0.0001019993,0.0008957782],"study_design_scores_gemma":[0.00005823513,0.0003248751,0.02626045,0.00001037493,0.00002859819,0.0008340473,0.00005628871,0.0008044725,0.9678326,0.00005590247,0.003727254,0.000006797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994837,0.001048802,0.0007896263,0.0001706203,0.00005909472,0.00001643173,0.0008923726,0.00007089716,0.002115106],"genre_scores_gemma":[0.9875864,0.001211972,0.001099761,0.0001234925,0.0000256044,0.00002788501,0.002468379,0.00002974837,0.007426878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001860348,"threshold_uncertainty_score":0.0062235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236814857880239,"score_gpt":0.2412956231291425,"score_spread":0.2289274745503401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}