{"id":"W2967946563","doi":"10.15252/msb.20188679","title":"CRISPR screens are feasible in TP53 wild‐type cells","year":2019,"lang":"en","type":"letter","venue":"Molecular Systems Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of Toronto","funders":"","keywords":"Library science; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002752313,0.0005230597,0.0006783786,0.000339134,0.0008183323,0.001821883,0.000677774,0.007922748,0.005232239],"category_scores_gemma":[0.009753747,0.0003016723,0.0005343258,0.0001925469,0.001929984,0.001187167,0.0009659929,0.01185154,0.007021663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001460024,"about_ca_system_score_gemma":0.0005152606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007825,"about_ca_topic_score_gemma":0.002140222,"domain_scores_codex":[0.9972515,0.0006309678,0.0001894995,0.000392385,0.001178993,0.0003567628],"domain_scores_gemma":[0.9926996,0.00502406,0.0004626091,0.0005511203,0.0008500572,0.0004126917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000266628,0.00007305064,0.001423146,0.0002669669,0.00004513573,0.005566321,0.0001720721,0.0003176972,0.04887809,0.02711157,0.8234725,0.09240684],"study_design_scores_gemma":[0.00007228135,0.0001252003,0.001336974,0.00008941241,0.00001966921,0.004117255,0.0001294291,0.0008235219,0.02415239,0.01856095,0.9505295,0.00004347691],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.006285588,0.009965292,0.01655061,0.906093,0.02307866,0.00006909829,0.0007033509,0.001570672,0.03568378],"genre_scores_gemma":[0.1487208,0.01736079,0.01690964,0.6998237,0.01999707,0.000352891,0.001059147,0.0005651414,0.09521086],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007922748,"threshold_uncertainty_score":0.01750362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049537648988766,"score_gpt":0.2958816565517814,"score_spread":0.2853862800618938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}