{"id":"W2967983128","doi":"10.1038/s41573-019-0035-2","title":"Progressive multiple sclerosis: from pathophysiology to therapeutic strategies","year":2019,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":457,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Alberta; University of Calgary","funders":"","keywords":"Multiple sclerosis; Pathophysiology; Medicine; Drug discovery; Neuroscience; Intensive care medicine; Bioinformatics; Immunology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001256657,0.001501792,0.003078905,0.004120353,0.0003533802,0.002208791,0.001362971,0.002120371,0.003879708],"category_scores_gemma":[0.00193177,0.0004025744,0.0007253222,0.003577757,0.0009281607,0.002021148,0.00141325,0.003045787,0.002180463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001295208,"about_ca_system_score_gemma":0.002478912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001719426,"about_ca_topic_score_gemma":0.004198036,"domain_scores_codex":[0.9995548,0.000109563,0.00007594151,0.00007014311,0.0001482772,0.0000413713],"domain_scores_gemma":[0.9990187,0.0005753731,0.0001021041,0.00002538735,0.000203399,0.00007503496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000161447,0.00008777162,0.0001402113,0.03626772,0.0001842122,0.000188012,0.00005630191,0.0004163083,0.0009428931,0.003997373,0.05967274,0.897885],"study_design_scores_gemma":[0.00007451866,0.0001034091,0.000594945,0.01310612,0.000342779,0.0006608958,0.00008893898,0.0001116388,0.000185976,0.003704871,0.9809945,0.00003131504],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001991945,0.9990885,0.0000535178,0.0002851825,0.0002314693,0.00000291681,0.00001122161,0.000004773539,0.0003024251],"genre_scores_gemma":[0.000169301,0.9989761,0.00009623398,0.0003254933,0.0002200181,0.000004367106,0.00001400527,8.006789e-7,0.0001935913],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004120353,"threshold_uncertainty_score":0.01297885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1272968573105799,"score_gpt":0.404576925344372,"score_spread":0.277280068033792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}