{"id":"W2967983128","doi":"10.1038/s41573-019-0035-2","title":"Progressive multiple sclerosis: from pathophysiology to therapeutic strategies","year":2019,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":457,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Alberta; University of Calgary","funders":"","keywords":"Multiple sclerosis; Pathophysiology; Medicine; Drug discovery; Neuroscience; Intensive care medicine; Bioinformatics; Immunology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0008231436,0.001511562,0.008481869,0.0004465825,0.0001717769,0.000313927,0.0009879515,0.00125937,0.0001504388],"category_scores_gemma":[0.001707601,0.0009064716,0.002517861,0.00102398,0.0002330243,0.0004861692,0.0007778445,0.003694609,0.001842426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004747612,"about_ca_system_score_gemma":0.001256258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005167212,"about_ca_topic_score_gemma":0.00003235282,"domain_scores_codex":[0.9928281,0.001359153,0.001776234,0.001917619,0.00101388,0.001105053],"domain_scores_gemma":[0.9945191,0.001447947,0.001042037,0.002330557,0.0002757307,0.0003846326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009770517,0.0002363504,0.00001792174,0.04475606,0.001032701,0.00004920988,0.0001514125,6.495806e-7,0.00009128438,0.00004621752,0.01757434,0.9359462],"study_design_scores_gemma":[0.0006054904,0.0001574239,0.0003019956,0.1189957,0.002052092,0.00001085796,0.0001312074,0.000002827981,0.000006026859,0.00004614734,0.876927,0.0007631762],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005103308,0.9815365,0.00002061833,0.0003355336,0.001067015,0.01557759,0.0008135752,0.0001150553,0.0004830589],"genre_scores_gemma":[0.000154635,0.9896899,0.0006722954,0.00117155,0.001714475,0.00428173,0.001159747,0.0002172943,0.0009383041],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.935183,"threshold_uncertainty_score":0.9997633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1272968573105799,"score_gpt":0.404576925344372,"score_spread":0.277280068033792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}