{"id":"W2968120913","doi":"10.1126/science.aax3649","title":"A dominant-negative effect drives selection of <i>TP53</i> missense mutations in myeloid malignancies","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":434,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Foundation Medicine; National Institute of General Medical Sciences; Instrumentariumin Tiedesäätiö; National Institutes of Health; Orionin Tutkimussäätiö; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Human Genome Research Institute; Henry and Marilyn Taub Foundation; Edward P. Evans Foundation; Howard Hughes Medical Institute; Celgene; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Leukemia and Lymphoma Society; AstraZeneca; Jane ja Aatos Erkon Säätiö; National Science Foundation","keywords":"Missense mutation; Biology; Genetics; Gene; Mutagenesis; Mutation; Tumor suppressor gene; Suppressor; Cancer research; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004153035,0.0002838893,0.0002726026,0.0001771964,0.0002087716,0.0008135313,0.0003588311,0.000434947,0.001421013],"category_scores_gemma":[0.0004699621,0.000191662,0.0001845277,0.0001135578,0.0005944137,0.0003767643,0.0003654416,0.001313676,0.0009410582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003696166,"about_ca_system_score_gemma":0.0002246639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003007597,"about_ca_topic_score_gemma":0.0005829597,"domain_scores_codex":[0.9997664,0.00004253437,0.00001544114,0.00004060904,0.00009089182,0.00004397715],"domain_scores_gemma":[0.9997088,0.00009891167,0.00005633979,0.00004078492,0.00003087448,0.00006421315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001519876,0.00003811322,0.001284837,0.00004792497,0.00001399925,0.0004643183,0.00005063353,0.000165058,0.9727887,0.004008392,0.004501102,0.01648488],"study_design_scores_gemma":[0.0001198112,0.0005685491,0.01392605,0.00004997045,0.00007533219,0.005584872,0.0002075326,0.003614544,0.8961966,0.006784927,0.07283268,0.00003920131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9244525,0.01494451,0.01639044,0.01714496,0.001127767,0.00006020829,0.0008351695,0.001264182,0.0237801],"genre_scores_gemma":[0.9809046,0.005966805,0.003648423,0.003213973,0.0002695002,0.00001868693,0.0002556546,0.0002370851,0.005485217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421013,"threshold_uncertainty_score":0.004753709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00899976534460787,"score_gpt":0.2973290718442946,"score_spread":0.2883293064996867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}