{"id":"W2968161214","doi":"10.3390/cells8080919","title":"The Combination of IFN β and TNF Induces an Antiviral and Immunoregulatory Program via Non-Canonical Pathways Involving STAT2 and IRF9","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montréal; McGill University; Génome Québec; Mitacs; University of Ottawa; Cleveland Clinic","keywords":"STAT2; STAT1; Interferon; Gene; STAT protein; Janus kinase; Tumor necrosis factor alpha; Biology; Transcription factor; Transcription (linguistics); STAT3; Signal transduction; Transcriptional regulation; Cell biology; Cancer research; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000301712,0.0001160949,0.000192942,0.00004770595,0.0001462897,0.00003464598,0.0000954742,0.0001465098,0.00001617653],"category_scores_gemma":[0.00001385548,0.00008308104,0.0000226673,0.00003807621,0.0004991977,0.0001351312,0.0001150516,0.0001754968,0.00001377294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009153736,"about_ca_system_score_gemma":0.00004471283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005019818,"about_ca_topic_score_gemma":0.000009710079,"domain_scores_codex":[0.9992127,0.0001910894,0.0001959736,0.000182111,0.00002485064,0.0001932936],"domain_scores_gemma":[0.9994915,0.0001765676,0.00009363199,0.0001796194,0.00004404334,0.00001463409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002135402,0.00009300011,0.001775073,0.00002934482,0.00004308828,5.222097e-7,0.0008812491,4.278643e-8,0.9419057,0.0005003573,0.00006152778,0.05449655],"study_design_scores_gemma":[0.001452636,0.001717025,0.1586475,0.00005865764,0.00002206348,0.00002209161,0.001255783,0.000065822,0.8329952,0.0001862325,0.003408736,0.000168231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929957,0.006046831,0.000003632323,0.00002768913,0.0002727419,0.0003178608,0.000005734762,0.00001796547,0.0003118647],"genre_scores_gemma":[0.9988087,0.0004930827,0.00002561052,0.0000241572,0.000005015622,0.000007422477,0.00001309789,0.00001000562,0.0006128487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1568724,"threshold_uncertainty_score":0.3387946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007634074845777863,"score_gpt":0.2263625529194042,"score_spread":0.2187284780736264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}