{"id":"W2968167834","doi":"10.1016/j.ahj.2019.08.001","title":"Effect of selective BET protein inhibitor apabetalone on cardiovascular outcomes in patients with acute coronary syndrome and diabetes: Rationale, design, and baseline characteristics of the BETonMACE trial","year":2019,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Resverlogix (Canada)","funders":"Sandoz; Merck Sharp and Dohme; Genentech; Sunovion; AbbVie; Takeda Pharmaceutical Company; Novo Nordisk; Medicines Company; Amarin Corporation; Shire; Abbott Laboratories; Sanofi; NIHR Imperial Biomedical Research Centre; Hospira; Amgen; Pfizer; Roche","keywords":"Medicine; Acute coronary syndrome; Clinical endpoint; Internal medicine; Myocardial infarction; Rosuvastatin; Placebo; Diabetes mellitus; Type 2 diabetes; Cardiology; Unstable angina; Stroke (engine); Atorvastatin; Randomized controlled trial; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001479814,0.001386313,0.002310761,0.0002327734,0.0003643237,0.001167616,0.0004852141,0.000891016,0.001660012],"category_scores_gemma":[0.001216478,0.000365001,0.001496446,0.0003399006,0.0006343673,0.000757717,0.0004158102,0.002022936,0.0003356501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005257134,"about_ca_system_score_gemma":0.0005858194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005208629,"about_ca_topic_score_gemma":0.001520941,"domain_scores_codex":[0.9994266,0.000278105,0.00003837707,0.00008921797,0.0000517903,0.0001158561],"domain_scores_gemma":[0.9995559,0.00009777716,0.00008970364,0.00004842607,0.00003234312,0.0001759282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9460866,0.004239384,0.008564693,0.0007800041,0.004009053,0.00006018672,0.00005015636,0.0006908267,0.005465345,0.0005239375,0.0009375353,0.02859233],"study_design_scores_gemma":[0.8302194,0.1021579,0.05298446,0.0001963875,0.006252482,0.0001364746,0.00009239551,0.001247715,0.00160119,0.001445863,0.003601579,0.00006394608],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9823484,0.01147984,0.0004589949,0.001012624,0.0003410391,0.0006413704,0.0006188108,0.00002768468,0.003071143],"genre_scores_gemma":[0.9906675,0.003840859,0.0006910276,0.001061312,0.0005309699,0.0008805886,0.000824722,0.0000108059,0.001492197],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.002310761,"threshold_uncertainty_score":0.007826149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003785645645748883,"score_gpt":0.2119135913261983,"score_spread":0.2081279456804494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}