{"id":"W2968198740","doi":"10.21451/1984-3143-ar2019-0062","title":"DNA methylation, environmental exposures and early embryo development","year":2019,"lang":"en","type":"article","venue":"Animal Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé","keywords":"Epigenome; Reprogramming; DNA methylation; Epigenetics; Biology; Embryo; Offspring; Cell biology; Embryogenesis; Methylation; Genetics; Pregnancy; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017257,0.00008660606,0.00006794138,0.00002926559,0.00006265406,0.00001872526,0.00003633235,0.00007031966,0.00002353949],"category_scores_gemma":[0.00003069625,0.0000878912,0.00002184906,0.00003068256,0.00002367529,0.000007567587,0.0000465037,0.00003798183,0.00003197583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001134081,"about_ca_system_score_gemma":0.00001600297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005807324,"about_ca_topic_score_gemma":0.000002091514,"domain_scores_codex":[0.9991935,0.00002932855,0.0001503608,0.0004188576,0.0001040207,0.0001038919],"domain_scores_gemma":[0.9996639,0.00000334966,0.0000603983,0.0002192394,0.00001880699,0.00003434285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004366576,0.00001859886,0.07543401,0.00000493373,0.00001438599,1.347687e-7,0.0001078253,0.00001126713,0.9104422,0.00002200415,0.00002134563,0.01387964],"study_design_scores_gemma":[0.0001033082,0.0001855349,0.4166831,0.000001471631,0.000003643304,0.000001547496,0.00003194507,0.0000029086,0.5637771,0.00003545872,0.01910172,0.00007221803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996112,0.002968363,0.0001508314,0.00005113846,0.0001345711,0.0001584839,9.411672e-7,0.000009043901,0.0004146051],"genre_scores_gemma":[0.9973773,0.0002234987,0.0008870952,0.00001146126,0.0001978055,0.000008227988,0.00003927689,0.00001281935,0.001242563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.346665,"threshold_uncertainty_score":0.3584099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007966461489571877,"score_gpt":0.2205042381087013,"score_spread":0.2125377766191294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}