{"id":"W2968198740","doi":"10.21451/1984-3143-ar2019-0062","title":"DNA methylation, environmental exposures and early embryo development","year":2019,"lang":"en","type":"article","venue":"Animal Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé","keywords":"Epigenome; Reprogramming; DNA methylation; Epigenetics; Biology; Embryo; Offspring; Cell biology; Embryogenesis; Methylation; Genetics; Pregnancy; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868796,0.0002792221,0.0002563357,0.0003680421,0.0002283941,0.0004216033,0.0002255127,0.0004386757,0.001616567],"category_scores_gemma":[0.0002308164,0.0001221406,0.0001818851,0.0003878104,0.0002974674,0.0002753587,0.0003619889,0.0004431479,0.0003282083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003972134,"about_ca_system_score_gemma":0.0003995401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001747298,"about_ca_topic_score_gemma":0.002652289,"domain_scores_codex":[0.9998839,0.00002536772,0.000009338068,0.00003284863,0.00002952765,0.00001905133],"domain_scores_gemma":[0.9999319,0.00001985966,0.00002105352,0.000003445087,0.00001464161,0.000008998047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005391532,0.0001026542,0.01517461,0.007604372,0.0003128099,0.002595559,0.001206044,0.001588986,0.5369884,0.01958981,0.005158995,0.4091386],"study_design_scores_gemma":[0.0000265547,0.0007963679,0.1707427,0.001331738,0.0003428755,0.005940408,0.001067491,0.001136348,0.2380773,0.01788559,0.5625326,0.0001200852],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.08075591,0.8924785,0.00826138,0.001455155,0.0003924202,0.00004505493,0.0007784064,0.0001085822,0.01572463],"genre_scores_gemma":[0.3638629,0.6181672,0.003766226,0.0004979738,0.0002100254,0.00005775705,0.0006076536,0.00001868831,0.01281167],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001747298,"threshold_uncertainty_score":0.005407929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007966461489571877,"score_gpt":0.2205042381087013,"score_spread":0.2125377766191294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}