{"id":"W2968378128","doi":"10.1002/ijc.32617","title":"Osimertinib confers potent binding affinity to EGFR kinase domain duplication","year":2019,"lang":"en","type":"letter","venue":"International Journal of Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Power Generation","funders":"National Natural Science Foundation of China","keywords":"Osimertinib; Afatinib; Gefitinib; Erlotinib; Epidermal growth factor receptor; Tyrosine kinase; Cancer research; Medicine; Protein kinase domain; Kinase; Exon; Lung cancer; Gene duplication; Cancer; Pharmacology; Oncology; Internal medicine; Biology; Receptor; Genetics; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009208618,0.0004289821,0.0007397773,0.0002859955,0.0002869996,0.0009702889,0.0008362549,0.002272342,0.00654453],"category_scores_gemma":[0.002330089,0.000208028,0.0004067239,0.0002304268,0.0004370383,0.0008647804,0.0003038693,0.003527042,0.004385452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003608044,"about_ca_system_score_gemma":0.0002653585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001245082,"about_ca_topic_score_gemma":0.0003566807,"domain_scores_codex":[0.9995847,0.00006507256,0.0000683252,0.00007449267,0.0001331937,0.00007422262],"domain_scores_gemma":[0.9988927,0.0004961757,0.000153461,0.00004564736,0.0002856864,0.0001263057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00105369,0.0001160872,0.002457598,0.001574078,0.0001090013,0.01042978,0.0001154649,0.0002148433,0.01696987,0.002649401,0.8247612,0.139549],"study_design_scores_gemma":[0.0001090022,0.0002544129,0.002051491,0.0001412816,0.0001006012,0.01355273,0.00009554029,0.0007607108,0.01271514,0.0007214447,0.969469,0.00002862101],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"editorial","genre_gemma":"empirical","genre_scores_codex":[0.04248584,0.1372535,0.004584244,0.3022407,0.4887301,0.0001280995,0.0007798329,0.0004429366,0.02335475],"genre_scores_gemma":[0.222288,0.08039778,0.003066484,0.1358977,0.4673334,0.000119424,0.0008123204,0.0001929077,0.08989199],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00654453,"threshold_uncertainty_score":0.02189362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0218197532764627,"score_gpt":0.3740240243295644,"score_spread":0.3522042710531017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}