{"id":"W2968439856","doi":"10.1101/19002063","title":"Early clinical markers of aggressive multiple sclerosis","year":2019,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Université de Montréal","funders":"Canadian Institutes of Health Research; Sanofi Genzyme; Novartis Pharma; Multiple Sclerosis Society; European Committee for Treatment and Research in Multiple Sclerosis; Multiple Sclerosis Society of Canada; Univerzita Karlova v Praze; Teva Pharmaceutical Industries; Biogen; Celgene; Fondazione Italiana Sclerosi Multipla; Sanofi","keywords":"Medicine; Multiple sclerosis; Internal medicine; Cohort; Expanded Disability Status Scale; Pediatrics; Disease; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003370203,0.000581594,0.0006401037,0.0007525937,0.0002441409,0.0008097023,0.0002969242,0.0003701201,0.001970384],"category_scores_gemma":[0.00723351,0.0002778887,0.0003815352,0.0006468318,0.0002769405,0.0005645792,0.0006790648,0.0009013935,0.0004618616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002406475,"about_ca_system_score_gemma":0.000299716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001986006,"about_ca_topic_score_gemma":0.001483997,"domain_scores_codex":[0.9989797,0.0004658914,0.0000887608,0.0001546794,0.0002008887,0.0001100315],"domain_scores_gemma":[0.9940712,0.002214167,0.002052293,0.0005624829,0.0006026026,0.0004972783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001693527,0.0002181344,0.9724077,0.00006483242,0.0001459839,0.0002404357,0.0001684916,0.003730576,0.004044509,0.0001176925,0.0005092947,0.01665872],"study_design_scores_gemma":[0.00006005158,0.0007379581,0.9842625,0.00003570495,0.00008313383,0.000629644,0.0000619827,0.0114569,0.001397469,0.0004560169,0.000796374,0.00002232838],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960251,0.0003695849,0.00182064,0.00004372717,0.00000555118,0.00005581122,0.0006575865,0.00004288362,0.0009790533],"genre_scores_gemma":[0.9979227,0.00005613052,0.0009218565,0.00001973833,0.000007227506,0.00002242183,0.0008846067,0.000005174323,0.000160118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003370203,"threshold_uncertainty_score":0.01782358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1563351538479721,"score_gpt":0.3763196604641869,"score_spread":0.2199845066162147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}