{"id":"W2968457722","doi":"10.1289/ehp4812","title":"Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate Metabolism","year":2019,"lang":"en","type":"article","venue":"Environmental Health Perspectives","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université Laval; CReATe Fertility Centre; Ministère de l'Agriculture, des Pêcheries et de l'Alimentation; McGill University and Génome Québec Innovation Centre; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Génome Québec; Compute Canada; McGill University","keywords":"DNA methylation; Methylenetetrahydrofolate reductase; Epigenetics; Sperm; Methylation; Biology; CpG site; Genetics; Genotype; Andrology; Medicine; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004564401,0.0003637175,0.0003192635,0.0004830067,0.0001890417,0.0001990774,0.0002991254,0.0005101349,0.001691961],"category_scores_gemma":[0.000779473,0.0002855863,0.0003728649,0.0004534424,0.000171682,0.00008327833,0.0003400374,0.0003164228,0.0004233666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002216748,"about_ca_system_score_gemma":0.0002714826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002822566,"about_ca_topic_score_gemma":0.007417924,"domain_scores_codex":[0.999562,0.0000691517,0.00002315389,0.0001798947,0.0001270549,0.00003880347],"domain_scores_gemma":[0.999732,0.00007254506,0.00005386908,0.00005450501,0.00006373958,0.00002332434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001686919,0.00004162349,0.008939845,0.0000575414,0.00009322885,0.00004803974,0.00007526589,0.001257912,0.9810619,0.00009529301,0.0001881953,0.007972549],"study_design_scores_gemma":[0.00006184843,0.001553896,0.1751644,0.0000228173,0.0003083542,0.0008361491,0.00008370039,0.01114391,0.8049635,0.0002175842,0.005610096,0.00003365984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9141127,0.0007002013,0.07647989,0.0000882482,0.00001961773,0.0004067766,0.005374923,0.0004969055,0.002320754],"genre_scores_gemma":[0.9083421,0.0004893407,0.0772119,0.0005905665,0.00001652206,0.0005213894,0.00876704,0.0001346598,0.003926444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002822566,"threshold_uncertainty_score":0.005660176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193347916160301,"score_gpt":0.3284094574070399,"score_spread":0.3090746657910098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}