{"id":"W2968457722","doi":"10.1289/ehp4812","title":"Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate Metabolism","year":2019,"lang":"en","type":"article","venue":"Environmental Health Perspectives","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université Laval; CReATe Fertility Centre; Ministère de l'Agriculture, des Pêcheries et de l'Alimentation; McGill University and Génome Québec Innovation Centre; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Génome Québec; Compute Canada; McGill University","keywords":"DNA methylation; Methylenetetrahydrofolate reductase; Epigenetics; Sperm; Methylation; Biology; CpG site; Genetics; Genotype; Andrology; Medicine; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001392706,0.0001805669,0.0003006995,0.0001046112,0.00009233895,0.0000148243,0.0002017434,0.00009469357,0.00008412957],"category_scores_gemma":[0.0000579019,0.0001481407,0.0001042774,0.0001363704,0.00006118685,0.00001331399,0.00009137713,0.0001583684,0.00001668686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000191536,"about_ca_system_score_gemma":0.00005663194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000445113,"about_ca_topic_score_gemma":0.00005341003,"domain_scores_codex":[0.9977105,0.0008051234,0.0004071396,0.0005051899,0.000306415,0.0002656429],"domain_scores_gemma":[0.9991822,0.00005409453,0.0002385054,0.0004316919,0.00001885503,0.00007460119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000989238,0.00009951759,0.001086862,0.00001475536,0.00004355151,4.528203e-7,0.03270061,0.0005239922,0.9649088,0.0002713903,0.00001432021,0.000236755],"study_design_scores_gemma":[0.004281055,0.001366195,0.4303298,0.00004582039,0.00006215243,0.000003943288,0.05950679,0.0002696319,0.5000545,0.002169218,0.001387433,0.0005234236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937532,0.003588546,0.000579907,0.000370497,0.0001059134,0.001032693,0.00003772642,0.000004567589,0.0005269579],"genre_scores_gemma":[0.9974108,0.0003642781,0.001566386,0.0002619281,0.0001136751,0.00004584225,0.00005436986,0.00002287116,0.0001598138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4648544,"threshold_uncertainty_score":0.6041002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193347916160301,"score_gpt":0.3284094574070399,"score_spread":0.3090746657910098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}