{"id":"W2968610608","doi":"10.1016/s2665-9913(19)30005-0","title":"Methotrexate withdrawal in patients with rheumatoid arthritis who achieve low disease activity with tofacitinib modified-release 11 mg once daily plus methotrexate (ORAL Shift): a randomised, phase 3b/4, non-inferiority trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Montreal Clinical Research Institute; Mount Sinai Hospital; Western University","funders":"Merck Sharp and Dohme; Pfizer","keywords":"Tofacitinib; Medicine; Rheumatoid arthritis; Methotrexate; Janus kinase inhibitor; Placebo; Internal medicine; Clinical endpoint; Erythrocyte sedimentation rate; Phases of clinical research; Clinical trial; Gastroenterology; Surgery; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0017408,0.0008707951,0.003324077,0.0003425565,0.0003373448,0.0001624985,0.0006686728,0.0002527173,0.0003250769],"category_scores_gemma":[0.0004806886,0.0005652908,0.0002923089,0.0006729257,0.0009212025,0.0006673234,0.0001862373,0.001388585,0.0001091796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866061,"about_ca_system_score_gemma":0.001075091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001365879,"about_ca_topic_score_gemma":0.001177215,"domain_scores_codex":[0.9932556,0.001662339,0.0009626324,0.001189982,0.001145217,0.001784232],"domain_scores_gemma":[0.9957513,0.0009487469,0.0006022683,0.001645012,0.0002653443,0.0007873208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7586436,0.001523381,0.2273264,0.000264011,0.0005279819,0.0003360137,0.001721195,0.0002748088,0.00004946216,0.0006229258,0.0001321733,0.008577993],"study_design_scores_gemma":[0.8620174,0.005033495,0.1221083,0.002479742,0.00005028716,0.0001612681,0.00022994,0.005616092,0.0002620422,0.0006884436,0.0003562382,0.0009967188],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890903,0.0007915545,0.001232103,0.001749034,0.00030409,0.005946143,0.0003040053,0.0001886273,0.0003941827],"genre_scores_gemma":[0.9945603,0.003608645,0.0004424524,0.0002647253,0.00005023228,0.0006773732,0.0001932869,0.0001303498,0.00007266203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1052181,"threshold_uncertainty_score":0.9996799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463993603832017,"score_gpt":0.2858968253415773,"score_spread":0.2712568893032572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}