{"id":"W2968663009","doi":"10.1038/s41569-019-0242-x","title":"Molecular genetic framework underlying pulmonary arterial hypertension","year":2019,"lang":"en","type":"review","venue":"Nature Reviews Cardiology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":317,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nutrasource","funders":"Medical Research Council; British Heart Foundation; Wellcome Trust","keywords":"Medicine; BMPR2; Penetrance; Pulmonary hypertension; Genetic disorder; Bioinformatics; Mendelian inheritance; Pulmonary artery; Cardiology; Disease; Coronary artery disease; Candidate gene; Internal medicine; Genetics; Gene; Phenotype; Biology; Bone morphogenetic protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0004686509,0.001021693,0.008334449,0.0004294286,0.000105357,0.00002816787,0.0004620552,0.003610563,0.0001007339],"category_scores_gemma":[0.0007761353,0.000650351,0.00301137,0.000594459,0.0001308084,0.00004529519,0.0002874626,0.003672349,0.001773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154004,"about_ca_system_score_gemma":0.0006993953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002541825,"about_ca_topic_score_gemma":1.092177e-7,"domain_scores_codex":[0.9946238,0.001376397,0.001135216,0.001382048,0.000576649,0.0009058977],"domain_scores_gemma":[0.996619,0.0004259418,0.0004210961,0.001900535,0.0001810546,0.0004524116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005148319,0.00009659457,0.00001909765,0.0196583,0.001172586,0.02612499,7.191258e-7,3.41119e-7,0.00002866444,0.00007276025,0.002564679,0.9502098],"study_design_scores_gemma":[0.0003374084,0.0002508669,0.0001447197,0.02333289,0.006204422,0.02585064,0.000001627127,0.00000453215,3.292977e-7,0.0001495338,0.9432576,0.0004654272],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002563529,0.9916754,0.00008911878,0.0001373289,0.001779386,0.004617414,0.00006121448,0.000078349,0.001536167],"genre_scores_gemma":[0.0001217245,0.9938079,0.00209576,0.001135411,0.0009579776,0.0003866087,0.00108962,0.0001650443,0.0002399358],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9497443,"threshold_uncertainty_score":0.9995947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1108632111116633,"score_gpt":0.4017965299894658,"score_spread":0.2909333188778025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}