{"id":"W2968674339","doi":"10.1021/acschembio.9b00608","title":"N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Cancer Institute; Crohn's and Colitis Canada; Australian Research Council; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; University of Melbourne; Crohn's and Colitis Foundation of Canada","keywords":"Proteases; Adherens junction; Protease; Proteolysis; Inflammation; Biology; Ulcerative colitis; Colitis; Immunology; Biochemistry; Cadherin; Cell; Enzyme; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196022,0.0002971075,0.0002153178,0.0004744136,0.0001305869,0.000257467,0.00009747037,0.0002932235,0.0005402873],"category_scores_gemma":[0.0002480011,0.0001306231,0.0001816892,0.0003113772,0.0001549134,0.0002094525,0.0001491159,0.0002664385,0.0002464724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000149903,"about_ca_system_score_gemma":0.0001002569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003795209,"about_ca_topic_score_gemma":0.0006150699,"domain_scores_codex":[0.9998925,0.00002478039,0.000008150114,0.00002421628,0.00002982837,0.00002061121],"domain_scores_gemma":[0.9998534,0.00003230372,0.00004835592,0.00001004692,0.00002763366,0.00002823848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003463044,0.000006981584,0.00120755,0.00003352848,0.000006860529,0.00005660746,0.00001520483,0.00004035296,0.9968556,0.0000209694,0.00001057978,0.001399338],"study_design_scores_gemma":[0.00001552134,0.0005093214,0.07960454,0.00001604399,0.00006236053,0.0009500076,0.00009214303,0.001550889,0.9147866,0.0001354569,0.002264674,0.0000124305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992783,0.00246216,0.003539495,0.00003100719,0.00000738213,0.00001617659,0.0003859833,0.00002166538,0.000753215],"genre_scores_gemma":[0.987626,0.001917376,0.007524153,0.00007602433,0.00001253871,0.00003404548,0.001136477,0.00002371025,0.001649536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005402873,"threshold_uncertainty_score":0.001807451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108449567705796,"score_gpt":0.2364933709813762,"score_spread":0.2256484142107966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}