{"id":"W2968674339","doi":"10.1021/acschembio.9b00608","title":"N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Cancer Institute; Crohn's and Colitis Canada; Australian Research Council; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; University of Melbourne; Crohn's and Colitis Foundation of Canada","keywords":"Proteases; Adherens junction; Protease; Proteolysis; Inflammation; Biology; Ulcerative colitis; Colitis; Immunology; Biochemistry; Cadherin; Cell; Enzyme; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395347,0.0001263529,0.0002248786,0.00002599527,0.00001079295,0.000005390911,0.0001189962,0.0002219024,0.00001733521],"category_scores_gemma":[0.00008344243,0.0001004254,0.00003668004,0.00003732841,0.0001142057,0.000003032714,0.00008379848,0.00006429986,0.000003756706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006041457,"about_ca_system_score_gemma":0.00003570945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001508655,"about_ca_topic_score_gemma":0.000007266753,"domain_scores_codex":[0.9992191,0.00007280897,0.0002032738,0.0002954046,0.00002082798,0.0001886128],"domain_scores_gemma":[0.9996327,0.00005156922,0.00007680345,0.000167559,0.0000339788,0.0000373605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001765261,0.00002750355,0.01156578,0.00002828484,0.00001697134,5.907115e-7,0.00003560479,3.180872e-7,0.9846784,0.0007868952,0.000003725412,0.00267943],"study_design_scores_gemma":[0.0003727444,0.0002109797,0.000736133,0.00001882746,0.000002416188,0.00001047681,0.00009235082,0.000007185623,0.9962748,0.001984125,0.0001702476,0.0001197556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987739,0.0003094866,0.00003775438,0.00004674605,0.00003256493,0.000396462,0.0000351016,0.00000452716,0.0003634569],"genre_scores_gemma":[0.9989691,0.00009307179,0.0006559689,0.00006345719,0.00004400339,0.00005308137,0.00007531662,0.000009555771,0.00003648875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01159639,"threshold_uncertainty_score":0.409523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108449567705796,"score_gpt":0.2364933709813762,"score_spread":0.2256484142107966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}