{"id":"W2968786184","doi":"10.1038/s41467-019-11370-y","title":"Gut-associated IgA+ immune cells regulate obesity-related insulin resistance","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Sinai Health System; Toronto Western Hospital; University of Alberta; Toronto General Hospital; University Health Network; University of Toronto; Discovery Centre","funders":"CIHR Skin Research Training Centre; Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Canadian Liver Foundation; Diabetes Canada; Government of Canada; University of Toronto","keywords":"Immune system; Intestinal permeability; Biology; Insulin resistance; Immunology; Inflammation; Microbiome; Immunoglobulin A; Adipose tissue; Adoptive cell transfer; Endocrinology; Internal medicine; T cell; Insulin; Medicine; Immunoglobulin G","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003314427,0.0002105645,0.0003096223,0.000165882,0.0004930064,0.00003205402,0.001026709,0.0009810288,0.002142639],"category_scores_gemma":[0.0001761949,0.0002106736,0.0001774802,0.0004868693,0.0001705825,0.0002127182,0.0002995614,0.002321634,0.006357776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001633663,"about_ca_system_score_gemma":0.00006192374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004187289,"about_ca_topic_score_gemma":0.000161093,"domain_scores_codex":[0.998282,0.0005499057,0.000515418,0.0002903518,0.00005716144,0.0003051275],"domain_scores_gemma":[0.9968286,0.0003342775,0.0003435409,0.002174281,0.0002984438,0.00002087958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001362454,0.0005561468,0.0009915353,0.00001152701,0.0003662773,7.716521e-7,0.0004905584,0.000009677699,0.9119862,0.01205008,0.07288193,0.0005190429],"study_design_scores_gemma":[0.00190343,0.00008154766,0.05731036,0.0001378467,0.00007981713,0.00001529151,0.0002922026,0.0000464184,0.04594698,0.0002985153,0.8934987,0.0003888735],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.661069,0.1104879,0.00002622754,0.009512374,0.01743244,0.001544737,0.00006554872,0.001018536,0.1988433],"genre_scores_gemma":[0.8552845,0.00120947,0.0001168647,0.0003255658,0.00000745855,0.00001926095,0.000973784,0.00002633937,0.1420368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8660392,"threshold_uncertainty_score":0.99998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006598870713535865,"score_gpt":0.2341503451452178,"score_spread":0.227551474431682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}