{"id":"W2968850985","doi":"10.1016/j.bioorg.2019.103194","title":"Design and synthesis of fluorogenic substrate-based probes for detecting Cathepsin B activity","year":2019,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Substrate specificity; Substrate (aquarium); Cathepsin B; Combinatorial chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002139947,0.0001517702,0.000167646,0.0000113688,0.00004345298,0.00001246993,0.00012394,0.0002001253,0.00002864041],"category_scores_gemma":[0.0001224268,0.0001501676,0.00007703741,0.00005032616,0.00003697081,0.000003704612,0.00004372578,0.00005332576,0.000002275023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001485827,"about_ca_system_score_gemma":0.0001578896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000560361,"about_ca_topic_score_gemma":6.403521e-7,"domain_scores_codex":[0.9992295,0.00002389995,0.0001438643,0.0003362613,0.00007533909,0.0001911566],"domain_scores_gemma":[0.9994261,0.00004778118,0.0001159367,0.0002947721,0.00005759385,0.0000578172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001510125,0.00006262807,0.0001226801,0.0002443124,0.00003279407,2.914469e-7,0.000006065641,0.000004560599,0.9984419,0.000001609392,0.00002694318,0.000905212],"study_design_scores_gemma":[0.0005137654,0.0001367492,0.0000249291,0.00003813687,0.00003107959,0.000007031966,0.00002100312,0.0003436219,0.998571,0.00003313955,0.0001028167,0.0001766672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930993,0.0003924088,0.005952411,0.00002066542,0.00002874576,0.0004176324,0.000015917,0.00001571027,0.00005725524],"genre_scores_gemma":[0.9971972,0.00001469475,0.002505019,0.00001549698,0.00007066361,0.0000625965,0.00001080467,0.00002878597,0.00009472921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004097955,"threshold_uncertainty_score":0.6123655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111252831439182,"score_gpt":0.2119894475761529,"score_spread":0.2008641644322347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}