{"id":"W2968850985","doi":"10.1016/j.bioorg.2019.103194","title":"Design and synthesis of fluorogenic substrate-based probes for detecting Cathepsin B activity","year":2019,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Substrate specificity; Substrate (aquarium); Cathepsin B; Combinatorial chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000864977,0.0006963046,0.0005111609,0.0004708947,0.0004040676,0.000552707,0.001054157,0.0008167681,0.001365949],"category_scores_gemma":[0.0006990577,0.0006585139,0.0004158054,0.0004943058,0.0004585272,0.000535049,0.0003220522,0.001159908,0.0006791066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008463145,"about_ca_system_score_gemma":0.0005551417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004718213,"about_ca_topic_score_gemma":0.0009086754,"domain_scores_codex":[0.9996005,0.00008832166,0.0000386113,0.00007191492,0.0001020496,0.0000987429],"domain_scores_gemma":[0.9995968,0.0001086864,0.00008526438,0.00004575784,0.00008301295,0.00008047656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001631766,0.00006586029,0.0000936954,0.0001277673,0.00001043678,0.0001206613,0.00006080269,0.0005823294,0.9921354,0.001165023,0.0001727329,0.005302045],"study_design_scores_gemma":[0.00002243537,0.0001718058,0.000136444,0.00000534311,0.000009513231,0.0001064103,0.00001263794,0.0007798945,0.9955384,0.0001020246,0.003106903,0.000008167574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6207048,0.005943446,0.3623711,0.0008054907,0.0001872097,0.001044394,0.001495935,0.001077598,0.006370227],"genre_scores_gemma":[0.7760116,0.004157067,0.2099109,0.0003460361,0.00005249174,0.0008620237,0.002204629,0.0001150578,0.006340218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365949,"threshold_uncertainty_score":0.006140471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111252831439182,"score_gpt":0.2119894475761529,"score_spread":0.2008641644322347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}