{"id":"W2968923062","doi":"10.1038/s41598-019-48196-z","title":"Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Instituto de Salud Carlos III; Junta de Castilla y León; Horizon 2020 Framework Programme; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable; Banco Bilbao Vizcaya Argentaria; European Commission; Fundación Ramón Areces; Fundación BBVA","keywords":"Neuroprotection; Glycolysis; Pentose phosphate pathway; Ischemia; Pharmacology; Reperfusion injury; Neurodegeneration; Excitotoxicity; Chemistry; Biochemistry; Fructose 2,6-bisphosphate; Programmed cell death; Cell biology; Biology; Phosphofructokinase; Medicine; Apoptosis; Enzyme; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007817185,0.0001247388,0.0001396866,0.00008609171,0.00008381321,0.00005821264,0.0001078473,0.0001644185,0.0005376369],"category_scores_gemma":[0.0002034654,0.0001152959,0.00007415827,0.0001743133,0.0000686411,0.000008143342,0.0001400189,0.000110585,0.0001342125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001313446,"about_ca_system_score_gemma":0.00008648333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002004826,"about_ca_topic_score_gemma":0.0000149837,"domain_scores_codex":[0.9983736,0.00005612931,0.0003651074,0.0007670053,0.000169428,0.0002687904],"domain_scores_gemma":[0.9991977,0.000006325697,0.0001542244,0.00049056,0.00008355929,0.00006759742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003130728,0.0000279768,0.02806658,0.00001008733,0.000003701501,0.00002419143,0.00006179996,0.00005701289,0.9409754,0.000007084392,0.03053433,0.0002005153],"study_design_scores_gemma":[0.0001551287,0.00005936633,0.0001484005,0.00001322858,0.000002900359,0.00007154809,0.0000650236,0.00005657942,0.8292484,0.0001233936,0.1699037,0.0001522893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875928,0.0002051092,0.00006176367,0.00007698509,0.008343449,0.0002256642,0.000001771057,0.00001641879,0.003476032],"genre_scores_gemma":[0.9826993,0.00001200469,0.0006539792,0.0001445656,0.0002017671,0.00001082582,0.00026544,0.00001464798,0.01599744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1393694,"threshold_uncertainty_score":0.5886747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00617368943062496,"score_gpt":0.2320982221892607,"score_spread":0.2259245327586357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}