{"id":"W2968923062","doi":"10.1038/s41598-019-48196-z","title":"Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Instituto de Salud Carlos III; Junta de Castilla y León; Horizon 2020 Framework Programme; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable; Banco Bilbao Vizcaya Argentaria; European Commission; Fundación Ramón Areces; Fundación BBVA","keywords":"Neuroprotection; Glycolysis; Pentose phosphate pathway; Ischemia; Pharmacology; Reperfusion injury; Neurodegeneration; Excitotoxicity; Chemistry; Biochemistry; Fructose 2,6-bisphosphate; Programmed cell death; Cell biology; Biology; Phosphofructokinase; Medicine; Apoptosis; Enzyme; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002596945,0.0009046019,0.0006726835,0.0005922574,0.0003208432,0.0003357884,0.0004126506,0.000686333,0.001845955],"category_scores_gemma":[0.0001066801,0.0002952185,0.0004161988,0.0002803237,0.0004678743,0.0004263223,0.0002188747,0.001263316,0.0005407347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000421763,"about_ca_system_score_gemma":0.0004756767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189699,"about_ca_topic_score_gemma":0.00180127,"domain_scores_codex":[0.9998173,0.00002055591,0.0000202472,0.00003902673,0.00003338566,0.0000694526],"domain_scores_gemma":[0.9998827,0.000006662136,0.00004295104,0.000009856748,0.00001085939,0.00004696676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001267578,0.0003309519,0.0001161781,0.0001352549,0.0000235315,0.00007802011,0.00003495307,0.000143358,0.993426,0.0002938224,0.0002455659,0.003904694],"study_design_scores_gemma":[0.0003330071,0.003574354,0.003437614,0.00004235419,0.00008698524,0.0003878513,0.00006073754,0.001727004,0.9853639,0.0002658466,0.004703044,0.00001722256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983798,0.004253027,0.006129439,0.0008764213,0.0002361629,0.0001608513,0.001108925,0.0007897709,0.002647453],"genre_scores_gemma":[0.9858446,0.002795635,0.003509125,0.0002250338,0.0000547905,0.0001829081,0.001012306,0.0000806385,0.006294926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001845955,"threshold_uncertainty_score":0.006175339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00617368943062496,"score_gpt":0.2320982221892607,"score_spread":0.2259245327586357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}