{"id":"W2968991328","doi":"10.1101/732339","title":"Reversible Mitochondrial Fragmentation in iPSC-Derived Cardiomyocytes from Children with DCMA, a Mitochondrial Cardiomyopathy","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Hotchkiss Brain Institute; St. Boniface Hospital; Alberta Children's Hospital; University of Manitoba; University of Calgary","funders":"Alberta Children's Hospital Foundation; Children's Hospital Foundation; Children's Cardiomyopathy Foundation; University of Calgary","keywords":"Induced pluripotent stem cell; Biology; Cardiolipin; Mitochondrion; mitochondrial fusion; Cell biology; Mitochondrial disease; Genetics; Mitochondrial DNA; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002619979,0.0002422776,0.0002254972,0.0003055886,0.0001692819,0.0002398521,0.0001777106,0.0003502975,0.001331237],"category_scores_gemma":[0.0002199108,0.0001007526,0.0002536657,0.0001873114,0.000203053,0.0001522859,0.0002924072,0.0004332049,0.0003772547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810155,"about_ca_system_score_gemma":0.0001330024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002190595,"about_ca_topic_score_gemma":0.0002828772,"domain_scores_codex":[0.9998183,0.00002365978,0.00003077781,0.00005300118,0.00005307158,0.00002136664],"domain_scores_gemma":[0.9998227,0.00003239862,0.0000501892,0.00002818064,0.0000246257,0.00004194653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002301386,0.00005377046,0.006661159,0.00009488475,0.00002375218,0.001746892,0.0001228041,0.0001849733,0.9860877,0.0001555553,0.000162233,0.004476033],"study_design_scores_gemma":[0.0001204732,0.001686554,0.1300782,0.00005120901,0.0001069899,0.02506653,0.0004245848,0.002340497,0.8323444,0.0003445006,0.007409263,0.00002685809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946852,0.0007230992,0.002479743,0.00006345835,0.00003517709,0.00005312484,0.0009565669,0.00005993997,0.0009436152],"genre_scores_gemma":[0.9950066,0.000404167,0.00216709,0.00007546932,0.00001101766,0.0000736834,0.001622511,0.00002273156,0.0006166845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331237,"threshold_uncertainty_score":0.004453421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008230420204808039,"score_gpt":0.2056660680045158,"score_spread":0.1974356477997078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}