{"id":"W2969087302","doi":"10.1172/jci127374","title":"Degradation of splicing factor SRSF3 contributes to progressive liver disease","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Diego; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; University of Minnesota; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Government of Ontario; U.S. Department of Veterans Affairs","keywords":"Splicing factor; Nonalcoholic fatty liver disease; RNA splicing; Cirrhosis; Hepatocellular carcinoma; Cancer research; Biology; Liver disease; Steatosis; Alternative splicing; Fatty liver; Internal medicine; Medicine; Endocrinology; RNA; Gene; Biochemistry; Exon; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006980051,0.00006826663,0.0002182109,0.00006516997,0.00002064612,0.00001849667,0.0001351854,0.00008411508,0.00001631992],"category_scores_gemma":[0.002828744,0.00005331016,0.0001384953,0.0000908183,0.00006697427,0.00001528893,0.00004329145,0.0001401384,0.000008729418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001122593,"about_ca_system_score_gemma":0.0002443548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007599418,"about_ca_topic_score_gemma":0.000003816042,"domain_scores_codex":[0.9986987,0.0001379685,0.0006907514,0.0001250542,0.0002322861,0.0001152036],"domain_scores_gemma":[0.9984593,0.0001143886,0.0005235061,0.0001338029,0.0004996156,0.0002693604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004820332,0.00005275181,0.3549977,0.0000387346,0.00006275209,0.000004375464,0.00001423205,0.0001279104,0.637596,0.0001379006,0.0007840055,0.005701606],"study_design_scores_gemma":[0.001368331,0.001460903,0.645508,0.0003143605,0.00004098061,0.000004712994,0.00003879364,0.001152639,0.348148,0.00039404,0.001447498,0.0001217242],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970191,0.0004191258,0.001446133,0.000714528,0.0001660598,0.0002064564,0.000006384595,0.000001632112,0.0000206193],"genre_scores_gemma":[0.9976265,0.00007749248,0.001280352,0.0003838803,0.0002173681,0.000001894016,0.00001480584,0.00000730706,0.0003903315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2905103,"threshold_uncertainty_score":0.3386475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0531995048928869,"score_gpt":0.3806341115405284,"score_spread":0.3274346066476415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}