{"id":"W2969087302","doi":"10.1172/jci127374","title":"Degradation of splicing factor SRSF3 contributes to progressive liver disease","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Diego; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; University of Minnesota; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Government of Ontario; U.S. Department of Veterans Affairs","keywords":"Splicing factor; Nonalcoholic fatty liver disease; RNA splicing; Cirrhosis; Hepatocellular carcinoma; Cancer research; Biology; Liver disease; Steatosis; Alternative splicing; Fatty liver; Internal medicine; Medicine; Endocrinology; RNA; Gene; Biochemistry; Exon; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001940993,0.0003481071,0.0002980707,0.0002070007,0.000120949,0.0001753007,0.00009414472,0.0002477128,0.001062883],"category_scores_gemma":[0.0001447746,0.0001118634,0.0002183749,0.0001238241,0.0002894933,0.0001017486,0.0001890594,0.000347107,0.0002556801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001378727,"about_ca_system_score_gemma":0.0001351228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003655918,"about_ca_topic_score_gemma":0.0004887969,"domain_scores_codex":[0.9999218,0.00001869186,0.000009824604,0.00001941789,0.00001860569,0.0000117017],"domain_scores_gemma":[0.9998862,0.00001287672,0.00005017435,0.000009721194,0.00001291559,0.00002822573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007211312,0.00003876005,0.008213756,0.0000820699,0.00003364924,0.001184722,0.00002955376,0.00008498054,0.9835418,0.0001709179,0.0001352603,0.005763207],"study_design_scores_gemma":[0.000135696,0.001385873,0.2796755,0.00004527553,0.0002283314,0.0215897,0.0001588615,0.002397588,0.6822705,0.0009557314,0.01113442,0.00002259084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928967,0.003506365,0.00233318,0.0001545782,0.00001843782,0.0000113702,0.0001312498,0.00008054536,0.0008675996],"genre_scores_gemma":[0.9967127,0.001405764,0.000670389,0.00005207258,0.00001333888,0.000005872693,0.0001488249,0.00001094488,0.0009801029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001062883,"threshold_uncertainty_score":0.003555655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0531995048928869,"score_gpt":0.3806341115405284,"score_spread":0.3274346066476415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}